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Slc26a7 solute carrier family 26 member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297910, updated on 11-Apr-2024

Summary

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Official Symbol
Slc26a7provided by RGD
Official Full Name
solute carrier family 26 member 7provided by RGD
Primary source
RGD:1310846
See related
Ensembl:ENSRNOG00000006096 AllianceGenome:RGD:1310846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable anion transmembrane transporter activity. Predicted to be involved in anion transport and gastric acid secretion. Predicted to act upstream of or within chloride transport. Located in basolateral plasma membrane. Orthologous to human SLC26A7 (solute carrier family 26 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 21.4), Kidney (RPKM 15.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc26a7 in Genome Data Viewer
Location:
5q13
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (32681653..32819110, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (27884400..28021865, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (27986656..28131294, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene 2 Neighboring gene leucine rich repeat containing 69 Neighboring gene OTU deubiquitinase 6B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Thyroglobulin regulates the expression and localization of the novel iodide transporter solute carrier family 26 member 7 (SLC26A7) in thyrocytes. Kiriya M, et al. Endocr J, 2022 Oct 28. PMID 35644541
  2. SLC26A7 can function as a chloride-loading mechanism in parietal cells. Kosiek O, et al. Pflugers Arch, 2007 Sep. PMID 17404755
  3. Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion. Xu J, et al. J Am Soc Nephrol, 2006 Apr. PMID 16524946
  4. SLC26A7 is a Cl- channel regulated by intracellular pH. Kim KH, et al. J Biol Chem, 2005 Feb 25. PMID 15591059
  5. Increased acid load and deletion of AE1 increase Slc26a7 expression. Sun X, et al. Nephron Physiol, 2008. PMID 18663336

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thyroglobulin regulates the expression and localization of the novel iodide transporter solute carrier family 26 member 7 (SLC26A7) in thyrocytes.
    Title: Thyroglobulin regulates the expression and localization of the novel iodide transporter solute carrier family 26 member 7 (SLC26A7) in thyrocytes.
  2. Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation.
    Title: SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.
  3. Suggest that the increase in Slc26a7 expression caused by acid challenge represents an adaptive response, indicating that Slc26a7 contributes to the regulation of acid-base balance by the kidney.
    Title: Increased acid load and deletion of AE1 increase Slc26a7 expression.
  4. SLC26A7 is a Cl(-) uptake system under histamine stimulation
    Title: SLC26A7 can function as a chloride-loading mechanism in parietal cells.
  5. vasopressin increases the expression of SLC26A7 protein through posttranscriptional mechanisms in the outer medullary collecting duct
    Title: Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bicarbonate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic anion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxalate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in gastric acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in gluconate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in iodide transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in nitrate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in oxalate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anion exchange transporter
Names
solute carrier family 26 (anion exchanger), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106638.1 → NP_001100108.1  anion exchange transporter

    See identical proteins and their annotated locations for NP_001100108.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473962
    UniProtKB/TrEMBL
    A6II93, D3Z8P6
    Related
    ENSRNOP00000058989.1, ENSRNOT00000067331.4
    Conserved Domains (2) summary
    cd07042
    Location:441 → 577
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:33 → 582
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    32681653..32819110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763531.4 → XP_008761753.1  anion exchange transporter isoform X4

    See identical proteins and their annotated locations for XP_008761753.1

    UniProtKB/TrEMBL
    A6II93, D3Z8P6
    Conserved Domains (2) summary
    cd07042
    Location:441 → 577
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:33 → 582
    sulP; high affinity sulphate transporter 1

  2. XM_063287292.1 → XP_063143362.1  anion exchange transporter isoform X3

  3. XM_063287291.1 → XP_063143361.1  anion exchange transporter isoform X2

    UniProtKB/TrEMBL
    A0A1W2Q625

  4. XM_006237911.5 → XP_006237973.1  anion exchange transporter isoform X2

    See identical proteins and their annotated locations for XP_006237973.1

    UniProtKB/TrEMBL
    A0A1W2Q625
    Related
    ENSRNOP00000076107.2
    Conserved Domains (2) summary
    cd07042
    Location:496 → 632
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:33 → 637
    sulP; high affinity sulphate transporter 1

  5. XM_039109419.2 → XP_038965347.1  anion exchange transporter isoform X1

    UniProtKB/TrEMBL
    A0A1W2Q610
    Related
    ENSRNOP00000076092.2
    Conserved Domains (1) summary
    TIGR00815
    Location:33 → 673
    sulP; high affinity sulphate transporter 1

  6. XM_039109418.2 → XP_038965346.1  anion exchange transporter isoform X1

    UniProtKB/TrEMBL
    A0A1W2Q610
    Conserved Domains (1) summary
    TIGR00815
    Location:33 → 673
    sulP; high affinity sulphate transporter 1

  7. XM_063287290.1 → XP_063143360.1  anion exchange transporter isoform X2

    UniProtKB/TrEMBL
    A0A1W2Q625

  8. XM_063287289.1 → XP_063143359.1  anion exchange transporter isoform X1

    UniProtKB/TrEMBL
    A0A1W2Q610

  9. XM_039109421.2 → XP_038965349.1  anion exchange transporter isoform X5

    Conserved Domains (2) summary
    cd07042
    Location:439 → 574
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:3 → 350
    Sulfate_transp; Sulfate permease family

  10. XM_039109422.2 → XP_038965350.1  anion exchange transporter isoform X6

    Conserved Domains (2) summary
    cd07042
    Location:372 → 507
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:1 → 283
    Sulfate_transp; Sulfate permease family
Nucleotide Protein Strain
Heading Accession and Version

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