Srsf12 serine and arginine rich splicing factor 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srsf12provided by RGD
Official Full Name: serine and arginine rich splicing factor 12provided by RGD
Primary source: RGD:1561162
See related: AllianceGenome:RGD:1561162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Srrp; Srrp35; RGD1561162
Summary: Predicted to enable RNA binding activity. Predicted to be involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nuclear speck. Orthologous to human SRSF12 (serine and arginine rich splicing factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 58.4), Testes (RPKM 47.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (52402033..52427839)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (47606526..47631509)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (48456777..48484017)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in mRNA 5'-splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 12

Names: 35 kDa SR repressor protein; 35 kDa serine-arginine repressor; serine-arginine repressor protein (35 kDa); serine-arginine repressor protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135711.2 → NP_001129183.1 serine/arginine-rich splicing factor 12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

Conserved Domains (1) summary

cd12559
Location:6 → 99

RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

52402033..52427839

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109432.2 → XP_038965360.2 serine/arginine-rich splicing factor 12 isoform X1
XM_039109433.2 → XP_038965361.1 serine/arginine-rich splicing factor 12 isoform X2

Conserved Domains (1) summary

cd12312
Location:2 → 72

RRM_SRSF10_SRSF12; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins