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Aldh1b1 aldehyde dehydrogenase 1 family, member B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298079, updated on 11-Apr-2024

Summary

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Official Symbol
Aldh1b1provided by RGD
Official Full Name
aldehyde dehydrogenase 1 family, member B1provided by RGD
Primary source
RGD:1306737
See related
Ensembl:ENSRNOG00000011497 AllianceGenome:RGD:1306737
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in ethanol catabolic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Orthologous to human ALDH1B1 (aldehyde dehydrogenase 1 family member B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 343.4) and Brain (RPKM 33.8) See more
Orthologs
human mouse all
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Genomic context

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Location:
5q22
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64859000..64864008)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60063370..60068378)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (61382351..61387359)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692348 Neighboring gene uncharacterized LOC134478962 Neighboring gene insulin-like growth factor binding protein-like 1 Neighboring gene STRA6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in ethanol catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase X, mitochondrial
Names
aldehyde dehydrogenase 1B1
aldehyde dehydrogenase family 1 member B1
NP_001011975.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011975.1 → NP_001011975.1  aldehyde dehydrogenase X, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001011975.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081884
    UniProtKB/Swiss-Prot
    Q66HF8
    UniProtKB/TrEMBL
    A6IJA2, G3V7I5
    Related
    ENSRNOP00000015282.3, ENSRNOT00000015281.5
    Conserved Domains (2) summary
    cd07141
    Location:33 → 513
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    PLN02466
    Location:13 → 510
    PLN02466; aldehyde dehydrogenase family 2 member

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    64859000..64864008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HF8.1 GenPept UniProtKB/Swiss-Prot:Q66HF8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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