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Tspan1 tetraspanin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298436, updated on 11-Apr-2024

Summary

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Official Symbol
Tspan1provided by RGD
Official Full Name
tetraspanin 1provided by RGD
Primary source
RGD:1303308
See related
Ensembl:ENSRNOG00000023320 AllianceGenome:RGD:1303308
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein stabilization. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and vesicle. Predicted to be integral component of plasma membrane. Orthologous to human TSPAN1 (tetraspanin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 142.7), Kidney (RPKM 141.2) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tspan1 in Genome Data Viewer
Location:
5q35
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134883704..134896083, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129646139..129659383, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135019206..135032412, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene leucine rich adaptor protein 1 Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene PIK3R3 upstream open reading frame Neighboring gene uncharacterized LOC120103122 Neighboring gene transfer RNA proline (anticodon AGG) 7 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis. Ferrero Restelli F, et al. Cell Mol Life Sci, 2020 Jun. PMID 31440771, Free PMC Article
  2. Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas. Wollscheid V, et al. Int J Cancer, 2002 Jun 20. PMID 12115476
  3. The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line. Wang GL, et al. Oncol Rep, 2012 Jun. PMID 22378020
  4. Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability. Nabokina SM, et al. Am J Physiol Gastrointest Liver Physiol, 2011 Nov. PMID 21836059, Free PMC Article
  5. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93753

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetraspanin-1
Names
tetraspan 1
tspan-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004236.1 → NP_001004236.1  tetraspanin-1

    See identical proteins and their annotated locations for NP_001004236.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078938
    UniProtKB/Swiss-Prot
    Q6AYR9
    UniProtKB/TrEMBL
    A0A8L2R5U0, A6JZ68
    Related
    ENSRNOP00000018766.3, ENSRNOT00000018766.5
    Conserved Domains (1) summary
    pfam00335
    Location:7 → 236
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    134883704..134896083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593274.3 → XP_017448763.1  tetraspanin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYR9
    UniProtKB/TrEMBL
    A0A8L2R5U0, A6JZ68
    Conserved Domains (1) summary
    pfam00335
    Location:7 → 236
    Tetraspannin; Tetraspanin family

  2. XM_006238639.4 → XP_006238701.1  tetraspanin-1 isoform X1

    See identical proteins and their annotated locations for XP_006238701.1

    UniProtKB/Swiss-Prot
    Q6AYR9
    UniProtKB/TrEMBL
    A0A8L2R5U0, A6JZ68
    Conserved Domains (1) summary
    pfam00335
    Location:7 → 236
    Tetraspannin; Tetraspanin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYR9.1 GenPept UniProtKB/Swiss-Prot:Q6AYR9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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