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Ppcs phosphopantothenoylcysteine synthetase [ Rattus norvegicus (Norway rat) ]

Gene ID: 298490, updated on 5-Mar-2024

Summary

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Official Symbol
Ppcsprovided by RGD
Official Full Name
phosphopantothenoylcysteine synthetaseprovided by RGD
Primary source
RGD:1311399
See related
Ensembl:ENSRNOG00000008572 AllianceGenome:RGD:1311399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311399
Summary
Predicted to enable phosphopantothenate--cysteine ligase activity and protein homodimerization activity. Predicted to be involved in acetyl-CoA biosynthetic process; coenzyme A biosynthetic process; and heart process. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 123.0), Kidney (RPKM 96.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (138308394..138312047, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (133023077..133026899, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (138466298..138470108, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486980 Neighboring gene coiled-coil domain containing 30 Neighboring gene transfer RNA alanine (anticodon AGC) 98 Neighboring gene zinc finger, MYND-type containing 12 Neighboring gene ribosomal modification protein rimK-like family member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. Iuso A, et al. Am J Hum Genet, 2018 Jun 7. PMID 29754768, Free PMC Article
  2. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Daugherty M, et al. J Biol Chem, 2002 Jun 14. PMID 11923312
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116383

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphopantothenate--cysteine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopantothenate--cysteine ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heart process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphopantothenate--cysteine ligase
NP_001034099.2
XP_008762220.1
XP_008762221.1
XP_063143501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039010.2 → NP_001034099.2  phosphopantothenate--cysteine ligase

    See identical proteins and their annotated locations for NP_001034099.2

    Status: VALIDATED

    Source sequence(s)
    BG378487, BQ195046, CK474267
    UniProtKB/TrEMBL
    A6JZP0, D4A6X7
    Related
    ENSRNOP00000011392.4, ENSRNOT00000011392.7
    Conserved Domains (1) summary
    cl04410
    Location:37 → 285
    DFP; DNA / pantothenate metabolizm flavoprotein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    138308394..138312047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763998.3 → XP_008762220.1  phosphopantothenate--cysteine ligase isoform X1

    See identical proteins and their annotated locations for XP_008762220.1

    UniProtKB/TrEMBL
    A6JZP1
    Conserved Domains (1) summary
    PRK05579
    Location:5 → 128
    PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated

  2. XM_008763999.4 → XP_008762221.1  phosphopantothenate--cysteine ligase isoform X1

    See identical proteins and their annotated locations for XP_008762221.1

    UniProtKB/TrEMBL
    A6JZP1
    Conserved Domains (1) summary
    PRK05579
    Location:5 → 128
    PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated

  3. XM_063287431.1 → XP_063143501.1  phosphopantothenate--cysteine ligase isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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