Grik3 glutamate ionotropic receptor kainate type subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grik3provided by RGD
Official Full Name: glutamate ionotropic receptor kainate type subunit 3provided by RGD
Primary source: RGD:71027
See related: Ensembl:ENSRNOG00000008992 AllianceGenome:RGD:71027
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GluK3; GluR7; gluR-7
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Compared to other kainate or AMPA receptors, this subunit exhibits a lower sensitivity to glutamate, and thus may play a unique role in neurotransmission in the brain. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Brain (RPKM 60.8) and Heart (RPKM 1.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (143052442..143268873)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (137767865..137989617)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (143500441..143715546)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery.
Title: Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery.
Our results suggest that mGluR2 and mGluR7 may contribute to the early rebalancing of spontaneous resting activity in the MVN
Title: The changes in mGluR2 and mGluR7 expression in rat medial vestibular nucleus and flocculus following unilateral labyrinthectomy.
Zinc binding stabilizes the labile GluK3 dimer interface, slows desensitization and potentiates currents.
Title: Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface.
the first X-ray crystal structure of the ligand binding domain of GluK3 in complex with glutamate, determined to 1.6A resolution, is presented.
Title: Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate.
adrenalectomy results in increased expression of hippocampal GluR7 mRNA, an effect which is reversed by treatment with corticosterone...
Title: Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus.
High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus.
Title: High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus.
We report a downstream link in the form of increased mitogen-activated protein (MAP) kinase activity, which may explain the long duration of metabotropic actions of kainate receptors on I(sAHP).
Title: Protein kinase signalling requirements for metabotropic action of kainate receptors in rat CA1 pyramidal neurones.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:479317 (e-PCR)
- UniSTS:479317

D5Jcs308 (e-PCR), detects polymorphism
- UniSTS:479317

D5Rat170 (e-PCR)
- UniSTS:240326

D5UIA4 (e-PCR)
- UniSTS:239852

D5UIA6 (e-PCR)
- UniSTS:239854

Glur7 (e-PCR)
- UniSTS:518639

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kainate selective glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables kainate selective glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
involved_in glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cochlear hair cell ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	TAS Traceable Author Statement more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, kainate 3

Names: glutamate receptor 7; glutamate receptor subunit kainate subtype; glutamate receptor, ionotropic, kainate 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112716.1 → NP_001106187.1 glutamate receptor ionotropic, kainate 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_001106187.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as GluR7a) encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000005, M83552, Z11716

UniProtKB/Swiss-Prot

O35420, P42264

UniProtKB/TrEMBL

A6IS78

Related

ENSRNOP00000089586.1, ENSRNOT00000103338.1

Conserved Domains (4) summary

cd06393
Location:34 → 417

PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor

cd13723
Location:433 → 801

PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily

pfam00060
Location:564 → 832

Lig_chan; Ligand-gated ion channel

pfam01094
Location:55 → 398

ANF_receptor; Receptor family ligand binding region
NM_181373.3 → NP_852038.2 glutamate receptor ionotropic, kainate 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_852038.2

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as GluR7b) uses a different donor splice site at the penultimate exon compared to transcript variant 1. This results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AF027331, JAXUCZ010000005, M83552

UniProtKB/Swiss-Prot

O35420, P42264

UniProtKB/TrEMBL

A6IS79, G3V9I2

Related

ENSRNOP00000048216.4, ENSRNOT00000045513.4

Conserved Domains (4) summary

cd06393
Location:34 → 417

PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor

cd13723
Location:433 → 801

PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily

pfam00060
Location:564 → 832

Lig_chan; Ligand-gated ion channel

pfam01094
Location:55 → 398

ANF_receptor; Receptor family ligand binding region