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Epha10 EPH receptor A10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298528, updated on 13-Apr-2024

Summary

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Official Symbol
Epha10provided by RGD
Official Full Name
EPH receptor A10provided by RGD
Primary source
RGD:1562679
See related
Ensembl:ENSRNOG00000037340 AllianceGenome:RGD:1562679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562679
Summary
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHA10 (EPH receptor A10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 42.0) and Testes (RPKM 12.4) See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142424260..142460305)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137139588..137175637)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (142875171..142910537)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 89 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene U6 spliceosomal RNA Neighboring gene cell division cycle associated 8 Neighboring gene AFG2 interacting ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. Aasheim HC, et al. Biochim Biophys Acta, 2005 May 25. PMID 15777695
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane-ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ephrin type-A receptor 10
NP_001382024.1
XP_017448782.1
XP_038965557.1
XP_063143510.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395095.1 → NP_001382024.1  ephrin type-A receptor 10 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    F1LX55
    Related
    ENSRNOP00000053334.5, ENSRNOT00000056496.5
    Conserved Domains (6) summary
    cd09549
    Location:928 → 997
    SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
    cd00063
    Location:451 → 551
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:339 → 431
    fn3; Fibronectin type III domain
    pfam14575
    Location:568 → 641
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:35 → 210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl21453
    Location:638 → 902
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    142424260..142460305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593293.3 → XP_017448782.1  ephrin type-A receptor 10 isoform X3

    UniProtKB/TrEMBL
    A6IS59

  2. XM_039109629.2 → XP_038965557.1  ephrin type-A receptor 10 isoform X1

    UniProtKB/TrEMBL
    F1LX55
    Conserved Domains (6) summary
    cd09549
    Location:982 → 1051
    SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
    cd00063
    Location:451 → 551
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:339 → 431
    fn3; Fibronectin type III domain
    pfam14575
    Location:568 → 641
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:35 → 210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl21453
    Location:638 → 956
    PKc_like; Protein Kinases, catalytic domain

  3. XM_063287440.1 → XP_063143510.1  ephrin type-A receptor 10 isoform X2

RNA

  1. XR_005504408.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135709.2: Suppressed sequence

    Description
    NM_001135709.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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