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Zfp593 zinc finger protein 593 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298546, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp593provided by RGD
Official Full Name
zinc finger protein 593provided by RGD
Primary source
RGD:1310179
See related
AllianceGenome:RGD:1310179
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf593
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human ZNF593 (zinc finger protein 593). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 31.0), Spleen (RPKM 30.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp593 in Genome Data Viewer
Location:
5q36
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151746396..151748724, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146462670..146464998, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152462522..152464850, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cation channel, sperm associated 4 Neighboring gene uncharacterized LOC120103003 Neighboring gene connector enhancer of kinase suppressor of Ras 1 Neighboring gene similar to human chromosome 1 open reading frame 230 Neighboring gene family with sequence similarity 110, member D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein. Hayes PL, et al. Protein Sci, 2008 Mar. PMID 18287285, Free PMC Article
  2. A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2. Terunuma A, et al. Nucleic Acids Res, 1997 May 15. PMID 9115366, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables preribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 593

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106689.1 → NP_001100159.1  zinc finger protein 593

    See identical proteins and their annotated locations for NP_001100159.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    B2GV37
    Conserved Domains (1) summary
    COG5112
    Location:1 → 108
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    151746396..151748724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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