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Prepl prolyl endopeptidase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 298771, updated on 11-Apr-2024

Summary

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Official Symbol
Preplprovided by RGD
Official Full Name
prolyl endopeptidase-likeprovided by RGD
Primary source
RGD:1310143
See related
Ensembl:ENSRNOG00000007326 AllianceGenome:RGD:1310143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310143
Summary
Predicted to enable peptidase activity. Predicted to be involved in Golgi to plasma membrane protein transport; regulation of synaptic vesicle exocytosis; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and nucleus. Predicted to be active in Golgi apparatus and cytoskeleton. Predicted to colocalize with trans-Golgi network. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 22. Orthologous to human PREPL (prolyl endopeptidase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 550.3), Heart (RPKM 330.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prepl in Genome Data Viewer
Location:
6q12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15333107..15362825)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (9580367..9609957)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (8316861..8346293, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479091 Neighboring gene solute carrier family 3 member 1 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1B Neighboring gene cilia- and flagella-associated protein 251-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PREPL deficiency: delineation of the phenotype and development of a functional blood assay. Régal L, et al. Genet Med, 2018 Jan. PMID 28726805
  2. PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome. Régal L, et al. Neurology, 2014 Apr 8. PMID 24610330, Free PMC Article
  3. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Lone AM, et al. J Am Chem Soc, 2011 Aug 3. PMID 21692504, Free PMC Article
  4. Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons. Morawski M, et al. Neuroscience, 2013 Jul 9. PMID 23485813
  5. Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit μ1A. Radhakrishnan K, et al. J Cell Sci, 2013 Mar 1. PMID 23321636

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC105586

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to plasma membrane protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
prolyl endopeptidase-like
NP_001010951.1
XP_006239759.1
XP_008762678.1
XP_008762680.1
XP_038967823.2
XP_063117671.1
XP_063117672.1
XP_063117673.1
XP_063117674.1
XP_063117675.1
XP_063117676.1
XP_063117677.1
XP_063117678.1
XP_063117679.1
XP_063117680.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010951.2 → NP_001010951.1  prolyl endopeptidase-like

    See identical proteins and their annotated locations for NP_001010951.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q5HZA6
    UniProtKB/TrEMBL
    A6H9H3
    Conserved Domains (1) summary
    COG1770
    Location:26 → 574
    PtrB; Protease II [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    15333107..15362825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261606.1 → XP_063117676.1  prolyl endopeptidase-like isoform X4

  2. XM_039111895.2 → XP_038967823.2  prolyl endopeptidase-like isoform X6

    UniProtKB/TrEMBL
    A0A8L2UN13

  3. XM_008764458.4 → XP_008762680.1  prolyl endopeptidase-like isoform X8

    See identical proteins and their annotated locations for XP_008762680.1

    UniProtKB/Swiss-Prot
    Q5HZA6
    UniProtKB/TrEMBL
    A6H9H3
    Conserved Domains (1) summary
    COG1770
    Location:26 → 574
    PtrB; Protease II [Amino acid transport and metabolism]

  4. XM_063261603.1 → XP_063117673.1  prolyl endopeptidase-like isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX67

  5. XM_063261610.1 → XP_063117680.1  prolyl endopeptidase-like isoform X8

    UniProtKB/TrEMBL
    A6H9H3

  6. XM_063261608.1 → XP_063117678.1  prolyl endopeptidase-like isoform X7

  7. XM_008764456.4 → XP_008762678.1  prolyl endopeptidase-like isoform X5

    UniProtKB/Swiss-Prot
    Q5HZA6
    Related
    ENSRNOP00000009660.7
    Conserved Domains (2) summary
    COG1770
    Location:91 → 639
    PtrB; Protease II [Amino acid transport and metabolism]
    cl21494
    Location:465 → 625
    Abhydrolase; alpha/beta hydrolases

  8. XM_063261601.1 → XP_063117671.1  prolyl endopeptidase-like isoform X1

  9. XM_063261602.1 → XP_063117672.1  prolyl endopeptidase-like isoform X1

  10. XM_006239697.5 → XP_006239759.1  prolyl endopeptidase-like isoform X2

    UniProtKB/Swiss-Prot
    Q5HZA6
    UniProtKB/TrEMBL
    A0A0G2JX67
    Related
    ENSRNOP00000076580.1
    Conserved Domains (2) summary
    COG1770
    Location:135 → 683
    PtrB; Protease II [Amino acid transport and metabolism]
    cl21494
    Location:509 → 669
    Abhydrolase; alpha/beta hydrolases

  11. XM_063261605.1 → XP_063117675.1  prolyl endopeptidase-like isoform X3

  12. XM_063261609.1 → XP_063117679.1  prolyl endopeptidase-like isoform X7

  13. XM_063261607.1 → XP_063117677.1  prolyl endopeptidase-like isoform X7

  14. XM_063261604.1 → XP_063117674.1  prolyl endopeptidase-like isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX67
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZA6.2 GenPept UniProtKB/Swiss-Prot:Q5HZA6

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