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Pum2 pumilio RNA-binding family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298874, updated on 6-Jun-2024

Summary

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Official Symbol
Pum2provided by RGD
Official Full Name
pumilio RNA-binding family member 2provided by RGD
Primary source
RGD:1311024
See related
Ensembl:ENSRNOG00000006180 AllianceGenome:RGD:1311024
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA 3'-UTR binding activity and miRNA binding activity. Predicted to be involved in positive regulation of RIG-I signaling pathway; regulation of chromosome segregation; and regulation of gene expression. Predicted to act upstream of or within stress granule assembly. Predicted to be located in cytoplasmic stress granule; nuclear membrane; and perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 341.7), Spleen (RPKM 285.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pum2 in Genome Data Viewer
Location:
6q14
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (37182130..37262223)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (31462879..31542976)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (33786184..33865693)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351200 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 Neighboring gene syndecan 1 Neighboring gene ribosomal protein S21, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function. Vessey JP, et al. Proc Natl Acad Sci U S A, 2010 Feb 16. PMID 20133610, Free PMC Article
  2. Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss. Yoon DS, et al. J Biomed Sci, 2023 Apr 23. PMID 37088847, Free PMC Article
  3. Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis. Cao Y, et al. Exp Cell Res, 2020 Aug 1. PMID 32437714
  4. Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability. Driscoll HE, et al. J Neurosci, 2013 Jun 5. PMID 23739961, Free PMC Article
  5. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. Fiore R, et al. EMBO J, 2009 Mar 18. PMID 19197241, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss.
    Title: Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss.
  2. Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis.
    Title: Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis.
  3. These results reveal that Pum2 shapes axonal transcriptomes by preventing the transport of Pumilio-binding elements -containing mRNAs into axons
    Title: Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body.
  4. Pumilio-2 is central to the homeostatic mechanism regulating membrane excitability in visual cortex pyramidal neurons.
    Title: Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability.
  5. Pumilio 2 regulates dendrite morphogenesis and synaptic function.
    Title: Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function.
  6. Mef2-induced expression of at least three individual miRNAs of the miR379-410 cluster is required for activity-dependent dendritic outgrowth of hippocampal neurons.
    Title: Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables lncRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables pumilio-response element binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in hair follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting of injured axon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pumilio homolog 2
Names
pumilio 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106715.1 → NP_001100185.1  pumilio homolog 2

    See identical proteins and their annotated locations for NP_001100185.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A0A8I6AD36, A6HAM2, D3ZQL8
    Related
    ENSRNOP00000008359.5, ENSRNOT00000008359.7
    Conserved Domains (1) summary
    cd07920
    Location:718 → 1039
    Pumilio; Pumilio-family RNA binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    37182130..37262223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239879.5 → XP_006239941.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006239941.1

    UniProtKB/TrEMBL
    A0A0G2K8F9, A0A8I6AD36
    Related
    ENSRNOP00000074592.2
    Conserved Domains (1) summary
    cd07920
    Location:722 → 1045
    Pumilio; Pumilio-family RNA binding domain

  2. XM_006239880.5 → XP_006239942.1  pumilio homolog 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AD36
    Conserved Domains (1) summary
    cd07920
    Location:722 → 1043
    Pumilio; Pumilio-family RNA binding domain

  3. XM_017594073.3 → XP_017449562.1  pumilio homolog 2 isoform X10

    Conserved Domains (1) summary
    cd07920
    Location:643 → 966
    Pumilio; Pumilio-family RNA binding domain

  4. XM_006239883.5 → XP_006239945.1  pumilio homolog 2 isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZSK1, A0A8I6AD36
    Related
    ENSRNOP00000081323.1
    Conserved Domains (1) summary
    cd07920
    Location:643 → 964
    Pumilio; Pumilio-family RNA binding domain

  5. XM_039111924.2 → XP_038967852.1  pumilio homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AD36
    Conserved Domains (1) summary
    cd07920
    Location:721 → 1044
    Pumilio; Pumilio-family RNA binding domain

  6. XM_039111925.2 → XP_038967853.1  pumilio homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AD36
    Conserved Domains (1) summary
    cd07920
    Location:721 → 1042
    Pumilio; Pumilio-family RNA binding domain

  7. XM_039111936.2 → XP_038967864.1  pumilio homolog 2 isoform X11

    Conserved Domains (1) summary
    cd07920
    Location:642 → 965
    Pumilio; Pumilio-family RNA binding domain

  8. XM_039111938.2 → XP_038967866.1  pumilio homolog 2 isoform X12

    UniProtKB/TrEMBL
    A0A8I6AD36
    Conserved Domains (1) summary
    cd07920
    Location:642 → 963
    Pumilio; Pumilio-family RNA binding domain

  9. XM_039111928.2 → XP_038967856.1  pumilio homolog 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AD36

  10. XM_063261634.1 → XP_063117704.1  pumilio homolog 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AD36

  11. XM_039111939.2 → XP_038967867.1  pumilio homolog 2 isoform X13

    UniProtKB/TrEMBL
    A0A8I6AD36
    Conserved Domains (1) summary
    cd07920
    Location:638 → 959
    Pumilio; Pumilio-family RNA binding domain

  12. XM_039111930.2 → XP_038967858.1  pumilio homolog 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AD36
    Conserved Domains (1) summary
    cd07920
    Location:716 → 1039
    Pumilio; Pumilio-family RNA binding domain

  13. XM_039111931.2 → XP_038967859.1  pumilio homolog 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AD36
    Conserved Domains (1) summary
    cd07920
    Location:716 → 1037
    Pumilio; Pumilio-family RNA binding domain

  14. XM_063261638.1 → XP_063117708.1  pumilio homolog 2 isoform X14

    UniProtKB/TrEMBL
    A0A8I6AD36

  15. XM_063261642.1 → XP_063117712.1  pumilio homolog 2 isoform X16

    UniProtKB/TrEMBL
    A0A8I6AD36

  16. XM_063261636.1 → XP_063117706.1  pumilio homolog 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6AD36

  17. XM_063261637.1 → XP_063117707.1  pumilio homolog 2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6AD36

  18. XM_063261633.1 → XP_063117703.1  pumilio homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8F9, A0A8I6AD36

  19. XM_063261635.1 → XP_063117705.1  pumilio homolog 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AD36

  20. XM_063261639.1 → XP_063117709.1  pumilio homolog 2 isoform X10

  21. XM_063261641.1 → XP_063117711.1  pumilio homolog 2 isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZSK1, A0A8I6AD36

  22. XM_063261640.1 → XP_063117710.1  pumilio homolog 2 isoform X11

  23. XM_063261643.1 → XP_063117713.1  pumilio homolog 2 isoform X17

  24. XM_063261644.1 → XP_063117714.1  pumilio homolog 2 isoform X18

Nucleotide Protein Strain
Heading Accession and Version

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