Osr1 odd-skipped related transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298878, updated on 2-May-2024

Summary

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Official Symbol: Osr1provided by RGD
Official Full Name: odd-skipped related transcription factor 1provided by RGD
Primary source: RGD:1311807
See related: AllianceGenome:RGD:1311807
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Odd1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including animal organ development; embryonic limb morphogenesis; and negative regulation of ion transmembrane transporter activity. Predicted to act upstream of or within animal organ development; cellular response to retinoic acid; and intermediate mesoderm development. Located in cytosol. Is extrinsic component of membrane. Orthologous to human OSR1 (odd-skipped related transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 31.2), Heart (RPKM 24.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Osr1 in Genome Data Viewer

Location:: 6q14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (38088688..38100010)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (32369561..32380822)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (35314431..35321458)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPAK and OSR1 may be critical factors in the regulation of depolarizing GABA-mediated processes in the developing brain.
Title: Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus.
Two Ste20-like kinases that bind and phosphorylate NKCC1: Ste20-related proline-alanine-rich kinase (SPAK) and oxidative-stress response 1 (OSR1), were identified.
Title: The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

Osr1 (e-PCR), detects polymorphism
- UniSTS:144080

Osr1 (e-PCR), detects polymorphism
- UniSTS:547582

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation involved in kidney development	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation involved in kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in embryo development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal joint development	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal joint morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal limb joint morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intermediate mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in mesangial cell development	ISO Inferred from Sequence Orthology more info
involved_in mesangial cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesonephric duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mesonephric duct morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric cap mesenchymal cell proliferation involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephric cap mesenchymal cell proliferation involved in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric epithelium development	ISO Inferred from Sequence Orthology more info
involved_in metanephric epithelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric glomerulus vasculature development	ISO Inferred from Sequence Orthology more info
involved_in metanephric glomerulus vasculature development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric interstitial fibroblast development	ISO Inferred from Sequence Orthology more info
involved_in metanephric interstitial fibroblast development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric mesenchymal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchymal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchyme development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric mesenchyme morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchyme morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric nephron tubule development	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron tubule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in metanephric smooth muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in middle ear morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in pattern specification involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in pattern specification involved in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gastrulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gastrulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in posterior mesonephric tubule development	ISO Inferred from Sequence Orthology more info
involved_in posterior mesonephric tubule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in pronephros development	IEA Inferred from Electronic Annotation more info
involved_in pronephros development	ISO Inferred from Sequence Orthology more info
involved_in pronephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in renal vesicle progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in renal vesicle progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in specification of anterior mesonephric tubule identity	ISO Inferred from Sequence Orthology more info
involved_in specification of anterior mesonephric tubule identity	ISS Inferred from Sequence or Structural Similarity more info
involved_in specification of posterior mesonephric tubule identity	ISO Inferred from Sequence Orthology more info
involved_in specification of posterior mesonephric tubule identity	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureter urothelium development	ISO Inferred from Sequence Orthology more info
involved_in ureter urothelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info
involved_in urogenital system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in urogenital system development	ISO Inferred from Sequence Orthology more info
involved_in urogenital system development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein odd-skipped-related 1

Names: odd-skipped related 1; odd-skipped related transciption factor 1

NP_001100186.1

EC 2.7.11.1

XP_038967869.1

EC 2.7.11.1

XP_063117715.1

EC 2.7.11.1

XP_063117716.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106716.4 → NP_001100186.1 protein odd-skipped-related 1

See identical proteins and their annotated locations for NP_001100186.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

B0K011

Conserved Domains (3) summary

sd00017
Location:177 → 197

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:175 → 197

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:189 → 214

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

38088688..38100010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111941.2 → XP_038967869.1 protein odd-skipped-related 1 isoform X1

UniProtKB/Swiss-Prot

B0K011

Conserved Domains (3) summary

sd00017
Location:177 → 197

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:175 → 197

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:189 → 214

zf-H2C2_2; Zinc-finger double domain
XM_063261645.1 → XP_063117715.1 protein odd-skipped-related 1 isoform X2

UniProtKB/TrEMBL

A0A8L2Q278
XM_063261646.1 → XP_063117716.1 protein odd-skipped-related 1 isoform X3