Kcnf1 potassium voltage-gated channel modifier subfamily F member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnf1provided by RGD
Official Full Name: potassium voltage-gated channel modifier subfamily F member 1provided by RGD
Primary source: RGD:631414
See related: Ensembl:ENSRNOG00000024310 AllianceGenome:RGD:631414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kh1; Kv5.1
Summary: Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in non-motile cilium assembly and potassium ion transmembrane transport. Predicted to be located in ciliary base. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Orthologous to human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (45691028..45693706, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (39962301..39964979, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (42471060..42473738, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in ciliary base	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily F member 1

Names: potassium channel, voltage-gated modifier subfamily F, member 1; potassium voltage-gated channel, subfamily F, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169104.1 → NP_001162575.1 potassium voltage-gated channel subfamily F member 1

See identical proteins and their annotated locations for NP_001162575.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HAU1, D4ADX7

Related

ENSRNOP00000033496.4, ENSRNOT00000033327.6

Conserved Domains (4) summary

smart00225
Location:37 → 147

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:234 → 429

Ion_trans; Ion transport protein

pfam07885
Location:343 → 412

Ion_trans_2; Ion channel

cl02518
Location:37 → 138

BTB; BTB/POZ domain