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Maea macrophage erythroblast attacher, E3 ubiquitin ligase [ Rattus norvegicus (Norway rat) ]

Gene ID: 298982, updated on 2-May-2024

Summary

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Official Symbol
Maeaprovided by RGD
Official Full Name
macrophage erythroblast attacher, E3 ubiquitin ligaseprovided by RGD
Primary source
RGD:1309877
See related
Ensembl:ENSRNOG00000005397 AllianceGenome:RGD:1309877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in cell adhesion; negative regulation of myeloid cell apoptotic process; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cytoskeleton organization and enucleate erythrocyte development. Predicted to be located in cytoskeleton and nuclear lumen. Predicted to be integral component of plasma membrane. Predicted to be part of GID complex and ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAEA (macrophage erythroblast attacher, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 333.0), Heart (RPKM 290.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Maea in Genome Data Viewer
Location:
14q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81581784..81615246, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77357261..77390683, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82664248..82697673, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene NK1 homeobox 1 Neighboring gene UV-stimulated scaffold protein A Neighboring gene uncharacterized LOC134481860 Neighboring gene uncharacterized LOC134481861 Neighboring gene C-terminal binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion. Soni S, et al. J Biol Chem, 2006 Jul 21. PMID 16707498
  2. Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. Bala S, et al. Biochem Biophys Res Commun, 2006 Apr 21. PMID 16510120
  3. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. Hanspal M, et al. Blood, 1998 Oct 15. PMID 9763581
  4. Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex. Francis O, et al. PLoS One, 2013. PMID 24143168, Free PMC Article
  5. RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. Kobayashi N, et al. Gene, 2007 Jul 15. PMID 17467196

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93683

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in enucleate erythrocyte development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enucleate erythrocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within erythrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of myeloid cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actomyosin contractile ring IEA
Inferred from Electronic Annotation
more info
  
located_in actomyosin contractile ring ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein transferase MAEA
NP_001008320.2
XP_038947726.1
XP_038947727.1
XP_063129083.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008319.2 → NP_001008320.2  E3 ubiquitin-protein transferase MAEA

    See identical proteins and their annotated locations for NP_001008320.2

    Status: VALIDATED

    Source sequence(s)
    BC085770, CV109439
    UniProtKB/Swiss-Prot
    Q5RKJ1
    UniProtKB/TrEMBL
    A0A8L2Q2K9, A6IK66
    Related
    ENSRNOP00000007181.5, ENSRNOT00000007181.6
    Conserved Domains (3) summary
    smart00667
    Location:120 → 153
    LisH; Lissencephaly type-1-like homology motif
    cd16659
    Location:336 → 383
    RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins
    pfam10607
    Location:160 → 301
    CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    81581784..81615246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273013.1 → XP_063129083.1  E3 ubiquitin-protein transferase MAEA isoform X1

  2. XM_039091799.2 → XP_038947727.1  E3 ubiquitin-protein transferase MAEA isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q2K9
    Conserved Domains (3) summary
    smart00667
    Location:72 → 105
    LisH; Lissencephaly type-1-like homology motif
    cd16659
    Location:288 → 335
    RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins
    pfam10607
    Location:112 → 253
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  3. XM_039091798.2 → XP_038947726.1  E3 ubiquitin-protein transferase MAEA isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q2K9
    Conserved Domains (3) summary
    smart00667
    Location:72 → 105
    LisH; Lissencephaly type-1-like homology motif
    cd16659
    Location:288 → 335
    RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins
    pfam10607
    Location:112 → 253
    CLTH; CTLH/CRA C-terminal to LisH motif domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RKJ1.2 GenPept UniProtKB/Swiss-Prot:Q5RKJ1

Gene LinkOut

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