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Prorp protein only RNase P catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 299050, updated on 2-May-2024

Summary

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Official Symbol
Prorpprovided by RGD
Official Full Name
protein only RNase P catalytic subunitprovided by RGD
Primary source
RGD:1305089
See related
Ensembl:ENSRNOG00000007043 AllianceGenome:RGD:1305089
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mrpp3; RGD1305089
Summary
Predicted to enable ribonuclease P activity. Predicted to be involved in mitochondrial tRNA 5'-end processing and tRNA 5'-leader removal. Predicted to be located in mitochondrial nucleoid and nucleoplasm. Predicted to be part of mitochondrial ribonuclease P complex. Orthologous to human PRORP (protein only RNase P catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 99.3), Thymus (RPKM 95.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prorp in Genome Data Viewer
Location:
6q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (78404821..78497562)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72669659..72762419)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (76079880..76171298)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700097009 gene like Neighboring gene signal recognition particle 54A Neighboring gene uncharacterized LOC134479210 Neighboring gene family with sequence similarity 177, member A1 Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene proteasome 20S subunit alpha 6 Neighboring gene NFKB inhibitor alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of the nuclease subunit of human mitochondrial RNase P. Reinhard L, et al. Nucleic Acids Res, 2015 Jun 23. PMID 25953853, Free PMC Article
  2. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Holzmann J, et al. Cell, 2008 Oct 31. PMID 18984158
  3. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Bogenhagen DF, et al. Cell Metab, 2014 Apr 1. PMID 24703694
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonuclease P activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA 5'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA 5'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial tRNA 5'-end processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial ribonuclease P complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial ribonuclease P catalytic subunit
Names
mitochondrial RNase P protein 3
mitochondrial ribonuclease P protein 3
NP_001100200.1
XP_038967903.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106730.2 → NP_001100200.1  mitochondrial ribonuclease P catalytic subunit precursor

    See identical proteins and their annotated locations for NP_001100200.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168878
    UniProtKB/Swiss-Prot
    B5DF07
    UniProtKB/TrEMBL
    A0A8I6AEM3
    Related
    ENSRNOP00000009306.4, ENSRNOT00000009304.5
    Conserved Domains (2) summary
    sd00004
    Location:174 → 204
    PPR; PPR repeat [structural motif]
    pfam16953
    Location:342 → 578
    PRORP; Protein-only RNase P

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    78404821..78497562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111975.2 → XP_038967903.1  mitochondrial ribonuclease P catalytic subunit isoform X1

    Conserved Domains (1) summary
    pfam16953
    Location:1 → 206
    PRORP; Protein-only RNase P
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5DF07.1 GenPept UniProtKB/Swiss-Prot:B5DF07

Gene LinkOut

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