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Nkx2-8 NK2 homeobox 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299061, updated on 5-Mar-2024

Summary

Official Symbol
Nkx2-8provided by RGD
Official Full Name
NK2 homeobox 8provided by RGD
Primary source
RGD:1310629
See related
Ensembl:ENSRNOG00000022970 AllianceGenome:RGD:1310629
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nkx2-9
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Predicted to act upstream of or within axonogenesis; lung development; and negative regulation of epithelial cell proliferation. Located in nucleus. Orthologous to human NKX2-8 (NK2 homeobox 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 6.9) See more
Orthologs
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Genomic context

Location:
6q23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (79821342..79823045, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (74086274..74087977, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (77506882..77508585, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene transcription factor BTF3-like Neighboring gene peptidase, mitochondrial processing subunit beta, pseudogene 2 Neighboring gene ribosomal protein L15, pseudogene 2 Neighboring gene solute carrier family 25 member 21 Neighboring gene paired box 9

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
homeobox protein Nkx-2.8
Names
NK2 transcription factor related, locus 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106732.1NP_001100202.1  homeobox protein Nkx-2.8

    See identical proteins and their annotated locations for NP_001100202.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A6HBN9, D4A7B5
    Related
    ENSRNOP00000011591.3, ENSRNOT00000011562.5
    Conserved Domains (1) summary
    pfam00046
    Location:84137
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    79821342..79823045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)