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Ttc8 tetratricopeptide repeat domain 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299246, updated on 3-Apr-2024

Summary

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Official Symbol
Ttc8provided by RGD
Official Full Name
tetratricopeptide repeat domain 8provided by RGD
Primary source
RGD:1307769
See related
Ensembl:ENSRNOG00000004542 AllianceGenome:RGD:1307769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in establishment of anatomical structure orientation and non-motile cilium assembly. Predicted to act upstream of or within several processes, including morphogenesis of a polarized epithelium; negative regulation of GTPase activity; and nervous system development. Predicted to be located in centrosome; membrane; and photoreceptor connecting cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 71.2), Kidney (RPKM 47.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttc8 in Genome Data Viewer
Location:
6q32
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123927657..124025354)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (118198186..118252422)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122920308..122974525)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479245 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene EMAP like 5 Neighboring gene uncharacterized LOC134479463 Neighboring gene uncharacterized LOC134479464 Neighboring gene candidate plasticity gene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alternative Isoform Analysis of Ttc8 Expression in the Rat Pineal Gland Using a Multi-Platform Sequencing Approach Reveals Neural Regulation. Hartley SW, et al. PLoS One, 2016. PMID 27684375, Free PMC Article
  2. Knockdown of Bardet-Biedl syndrome gene BBS9/PTHB1 leads to cilia defects. Veleri S, et al. PLoS One, 2012. PMID 22479622, Free PMC Article
  3. Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization. Hernandez-Hernandez V, et al. Hum Mol Genet, 2013 Oct 1. PMID 23716571, Free PMC Article
  4. Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Tadenev AL, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21646512, Free PMC Article
  5. Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. Broekhuis JR, et al. PLoS One, 2014. PMID 25243405, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within camera-type eye photoreceptor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of anatomical structure orientation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of planar polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multi-ciliated epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within olfactory bulb development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within renal tubule development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of BBSome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BBSome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in photoreceptor connecting cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106752.1 → NP_001100222.1  tetratricopeptide repeat protein 8 isoform 2

    See identical proteins and their annotated locations for NP_001100222.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/TrEMBL
    A0A8I5ZJC8, A6JEF4, D3ZND5
    Related
    ENSRNOP00000060304.1, ENSRNOT00000068595.3
    Conserved Domains (2) summary
    sd00006
    Location:202 → 225
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:231 → 294
    TPR_11; TPR repeat

  2. NM_001399497.1 → NP_001386426.1  tetratricopeptide repeat protein 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    B1WBT5
    Related
    ENSRNOP00000068618.1, ENSRNOT00000082856.2
    Conserved Domains (3) summary
    COG0457
    Location:231 → 488
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:350 → 378
    TPR; TPR repeat [structural motif]
    cd21341
    Location:30 → 169
    TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

  3. NM_001399499.1 → NP_001386428.1  tetratricopeptide repeat protein 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A1P8YVD0
    Related
    ENSRNOP00000085100.1, ENSRNOT00000094428.1
    Conserved Domains (3) summary
    COG0457
    Location:241 → 498
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:360 → 388
    TPR; TPR repeat [structural motif]
    cd21341
    Location:30 → 179
    TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    123927657..124025354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112066.2 → XP_038967994.1  tetratricopeptide repeat protein 8 isoform X4

    UniProtKB/TrEMBL
    A0A1P8YVD4
    Conserved Domains (3) summary
    smart00028
    Location:220 → 246
    TPR; Tetratricopeptide repeats
    sd00006
    Location:182 → 208
    TPR; TPR repeat [structural motif]
    cd21341
    Location:30 → 169
    TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

  2. XM_039112069.2 → XP_038967997.1  tetratricopeptide repeat protein 8 isoform X6

    UniProtKB/TrEMBL
    A0A1P8YVD8, A0A1P8YVF9
    Related
    ENSRNOP00000085312.1
    Conserved Domains (3) summary
    smart00028
    Location:220 → 246
    TPR; Tetratricopeptide repeats
    sd00006
    Location:181 → 209
    TPR; TPR repeat [structural motif]
    cd21341
    Location:30 → 169
    TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

  3. XM_063261761.1 → XP_063117831.1  tetratricopeptide repeat protein 8 isoform X3

  4. XM_063261759.1 → XP_063117829.1  tetratricopeptide repeat protein 8 isoform X1

  5. XM_063261760.1 → XP_063117830.1  tetratricopeptide repeat protein 8 isoform X2

  6. XM_039112067.2 → XP_038967995.1  tetratricopeptide repeat protein 8 isoform X5

    UniProtKB/TrEMBL
    A0A1P8YVE4
    Related
    ENSRNOP00000093561.1
    Conserved Domains (2) summary
    TIGR02917
    Location:129 → 269
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:130 → 158
    TPR; TPR repeat [structural motif]

RNA

  1. XR_010052075.1 RNA Sequence

  2. XR_010052074.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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