Dctn2 dynactin subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dctn2provided by RGD
Official Full Name: dynactin subunit 2provided by RGD
Primary source: RGD:1303182
See related: Ensembl:ENSRNOG00000025481 AllianceGenome:RGD:1303182
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Involved in mitotic spindle organization. Located in centrosome and kinetochore. Part of dynactin complex. Biomarker of synucleinopathy. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 539.9), Lung (RPKM 406.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (64977338..64992875)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63092061..63107560)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70555953..70571433)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C87049 (e-PCR)
- UniSTS:160051

RH127945 (e-PCR)
- UniSTS:211255

RH136664 (e-PCR)
- UniSTS:218755

D10Wsu93e (e-PCR), detects polymorphism
- UniSTS:141531

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	IEA Inferred from Electronic Annotation more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in melanosome transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of dynactin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dynactin complex	IDA Inferred from Direct Assay more info	PubMed
part_of dynactin complex	IEA Inferred from Electronic Annotation more info
part_of dynactin complex	ISO Inferred from Sequence Orthology more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dynactin subunit 2

Names: dynactin 2 (p50)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004239.1 → NP_001004239.1 dynactin subunit 2

See identical proteins and their annotated locations for NP_001004239.1

Status: PROVISIONAL

Source sequence(s)

BC079042

UniProtKB/Swiss-Prot

Q6AYH5

UniProtKB/TrEMBL

A0A0G2JUC7, A6HQT8

Related

ENSRNOP00000008120.4, ENSRNOT00000008120.5

Conserved Domains (1) summary

pfam04912
Location:16 → 400

Dynamitin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

64977338..64992875

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078753.2 → XP_038934681.1 dynactin subunit 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JUC7

Conserved Domains (1) summary

pfam04912
Location:16 → 374

Dynamitin
XM_039078754.2 → XP_038934682.1 dynactin subunit 2 isoform X2

UniProtKB/TrEMBL

A0A0G2JUC7

Conserved Domains (1) summary

pfam04912
Location:13 → 377

Dynamitin