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Lrp1 LDL receptor related protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299858, updated on 4-Jan-2025

Summary

Official Symbol
Lrp1provided by RGD
Official Full Name
LDL receptor related protein 1provided by RGD
Primary source
RGD:1307535
See related
EnsemblRapid:ENSRNOG00000025053 AllianceGenome:RGD:1307535
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRP-1
Summary
Enables coreceptor activity; protease binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of transport; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 783.5), Adrenal (RPKM 435.3) and 9 other tissues See more
Orthologs
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Genomic context

See Lrp1 in Genome Data Viewer
Location:
7q22
Exon count:
90
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65265639..65346196, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63380325..63461029, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70846313..70927028, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NDUFA4, mitochondrial complex associated like 2 Neighboring gene serine hydroxymethyltransferase 2 Neighboring gene neurexophilin 4 Neighboring gene uncharacterized LOC120093805 Neighboring gene uncharacterized LOC134479886 Neighboring gene uncharacterized LOC134479889

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-2 macroglobulin receptor activity  
enables alpha-2 macroglobulin receptor activity  
enables apolipoprotein binding  
enables apolipoprotein binding  
enables apolipoprotein binding  
enables calcium ion binding  
enables calcium ion binding  
enables cargo receptor activity  
enables cargo receptor activity  
enables clathrin heavy chain binding  
enables clathrin heavy chain binding  
enables coreceptor activity PubMed 
enables protease binding PubMed 
enables protein binding PubMed 
enables protein serine/threonine kinase binding PubMed 
enables protein-containing complex binding  
enables protein-containing complex binding  
enables signaling receptor binding  
Items 1 - 25 of 71
Process Evidence Code Pubs
involved_in amyloid-beta clearance  
involved_in amyloid-beta clearance by cellular catabolic process  
involved_in amyloid-beta clearance by cellular catabolic process  
involved_in amyloid-beta clearance by cellular catabolic process  
involved_in amyloid-beta clearance by transcytosis  
involved_in amyloid-beta clearance by transcytosis  
involved_in amyloid-beta clearance by transcytosis  
involved_in aorta morphogenesis  
acts_upstream_of_or_within apoptotic cell clearance  
involved_in astrocyte activation involved in immune response  
acts_upstream_of_or_within cardiac septum development  
involved_in cellular response to amyloid-beta  
involved_in cerebral cortex development PubMed 
involved_in chemoattraction of axon PubMed 
acts_upstream_of_or_within cholesterol metabolic process  
acts_upstream_of_or_within coronary vasculature development  
involved_in enzyme-linked receptor protein signaling pathway  
involved_in lysosomal transport  
involved_in negative regulation of SMAD protein signal transduction  
acts_upstream_of_or_within negative regulation of Wnt signaling pathway  
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of cell-substrate adhesion PubMed 
involved_in negative regulation of cytosolic calcium ion concentration PubMed 
involved_in negative regulation of endopeptidase activity PubMed 
involved_in negative regulation of focal adhesion assembly PubMed 
involved_in negative regulation of gene expression  
involved_in negative regulation of neuron apoptotic process PubMed 
involved_in negative regulation of neuron apoptotic process PubMed 
involved_in negative regulation of neuron projection development PubMed 
involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway  
involved_in negative regulation of smooth muscle cell migration  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
involved_in phagocytosis  
involved_in phagocytosis  
involved_in phagocytosis  
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of Schwann cell migration PubMed 
involved_in positive regulation of amyloid-beta clearance  
involved_in positive regulation of axon extension PubMed 
involved_in positive regulation of axon extension involved in regeneration PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production PubMed 
involved_in positive regulation of cholesterol efflux  
involved_in positive regulation of cholesterol import PubMed 
involved_in positive regulation of cholesterol transport  
involved_in positive regulation of collateral sprouting of injured axon PubMed 
involved_in positive regulation of cytosolic calcium ion concentration PubMed 
involved_in positive regulation of endocytosis  
involved_in positive regulation of endocytosis  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
involved_in positive regulation of lipid transport  
involved_in positive regulation of lysosomal protein catabolic process  
involved_in positive regulation of lysosomal protein catabolic process  
involved_in positive regulation of neuron projection development PubMed 
involved_in positive regulation of phagocytosis PubMed 
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein transport PubMed 
involved_in positive regulation of transcytosis  
involved_in positive regulation of vascular associated smooth muscle cell migration PubMed 
involved_in receptor internalization  
involved_in receptor-mediated endocytosis  
involved_in receptor-mediated endocytosis  
involved_in receptor-mediated endocytosis PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis  
involved_in receptor-mediated endocytosis  
involved_in regulation of actin cytoskeleton organization  
involved_in regulation of cholesterol transport  
involved_in regulation of phospholipase A2 activity  
involved_in regulation of postsynaptic neurotransmitter receptor internalization  
involved_in regulation of pulmonary blood vessel remodeling  
involved_in transport across blood-brain barrier  
Items 1 - 25 of 71
Items 1 - 20 of 26
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in apical part of cell PubMed 
located_in axonal growth cone PubMed 
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in clathrin-coated pit  
located_in clathrin-coated vesicle PubMed 
located_in dendrite PubMed 
located_in early endosome  
located_in early endosome  
located_in early endosome PubMed 
located_in endosome PubMed 
located_in external side of plasma membrane  
is_active_in glutamatergic synapse  
located_in insulin-responsive compartment PubMed 
part_of low-density lipoprotein receptor complex PubMed 
located_in membrane  
located_in microtubule organizing center  
located_in neuronal cell body PubMed 
located_in nucleus  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane PubMed 
is_active_in postsynaptic density membrane  
part_of receptor complex  
part_of receptor complex  
Items 1 - 20 of 26

General protein information

Preferred Names
prolow-density lipoprotein receptor-related protein 1
Names
low density lipoprotein receptor-related protein 1
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130490.1NP_001123962.1  prolow-density lipoprotein receptor-related protein 1 precursor

    See identical proteins and their annotated locations for NP_001123962.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/Swiss-Prot
    G3V928, Q5I0H1
    Related
    ENSRNOP00000034210.4, ENSRNOT00000031005.7
    Conserved Domains (9) summary
    smart00192
    Location:34943527
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:30953137
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:29833012
    EGF_CA; Calcium-binding EGF-like domain
    COG3386
    Location:22542464
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd00112
    Location:35763610
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:40144054
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:29632986
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:808843
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00104
    Location:72109
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    65265639..65346196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765393.3XP_008763615.1  prolow-density lipoprotein receptor-related protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0U0
    Related
    ENSRNOP00000085719.1, ENSRNOT00000108298.2
    Conserved Domains (8) summary
    smart00192
    Location:35113544
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:31123154
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:30003029
    EGF_CA; Calcium-binding EGF-like domain
    COG3386
    Location:22712481
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd00112
    Location:35933627
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:40314071
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:29803003
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:808843
    FXa_inhibition; Coagulation Factor Xa inhibitory site
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