Colec10 collectin subfamily member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Colec10provided by RGD
Official Full Name: collectin subfamily member 10provided by RGD
Primary source: RGD:1307149
See related: Ensembl:ENSRNOG00000008591 AllianceGenome:RGD:1307149
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chemoattractant activity and mannose binding activity. Predicted to be involved in cranial skeletal system development. Predicted to be located in cytoplasm. Predicted to be part of collagen trimer. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in 3MC syndrome 3. Orthologous to human COLEC10 (collectin subfamily member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 164.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (87634686..87695465)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (85744895..85806368)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (93975451..94035999)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables mannose binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in complement activation, lectin pathway	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: collectin-10

Names: collectin sub-family member 10 (C-type lectin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130541.1 → NP_001124013.1 collectin-10 precursor

See identical proteins and their annotated locations for NP_001124013.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A6HRF8, D4A7F6

Related

ENSRNOP00000011379.4, ENSRNOT00000011379.5

Conserved Domains (2) summary

cd03591
Location:157 → 272

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:45 → 94

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

87634686..87695465

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078785.2 → XP_038934713.1 collectin-10 isoform X1

Conserved Domains (1) summary

cd03591
Location:76 → 191

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)