Zc3h3 zinc finger CCCH type containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zc3h3provided by RGD
Official Full Name: zinc finger CCCH type containing 3provided by RGD
Primary source: RGD:1307276
See related: Ensembl:ENSRNOG00000007684 AllianceGenome:RGD:1307276
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zc3hdc3
Summary: Predicted to enable R-SMAD binding activity. Predicted to be involved in regulation of mRNA polyadenylation. Predicted to act upstream of or within mRNA 3'-end processing and positive regulation of activin receptor signaling pathway. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nucleus. Orthologous to human ZC3H3 (zinc finger CCCH-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 45.7), Lung (RPKM 43.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109321423..109406241, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (107440694..107525451, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (116787762..116872536, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger CCCH domain-containing protein 3

Names: zinc finger CCCH type domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134865.1 → NP_001128337.1 zinc finger CCCH domain-containing protein 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6GIY9, D3ZKY5

Related

ENSRNOP00000010120.4, ENSRNOT00000010120.6

Conserved Domains (2) summary

smart00356
Location:746 → 772

ZnF_C3H1; zinc finger

pfam00642
Location:664 → 690

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109321423..109406241 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263275.1 → XP_063119345.1 zinc finger CCCH domain-containing protein 3 isoform X1
XM_063263276.1 → XP_063119346.1 zinc finger CCCH domain-containing protein 3 isoform X2
XM_063263277.1 → XP_063119347.1 zinc finger CCCH domain-containing protein 3 isoform X2
XM_063263278.1 → XP_063119348.1 zinc finger CCCH domain-containing protein 3 isoform X3