Tomm22 translocase of outer mitochondrial membrane 22 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tomm22provided by RGD
Official Full Name: translocase of outer mitochondrial membrane 22provided by RGD
Primary source: RGD:1303260
See related: Ensembl:ENSRNOG00000014058 AllianceGenome:RGD:1303260
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TOM22; rTOM22
Summary: Enables protein transmembrane transporter activity. Involved in positive regulation of apoptotic process; protein insertion into mitochondrial membrane; and protein targeting to mitochondrion. Located in mitochondrion. Part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM22 (translocase of outer mitochondrial membrane 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 483.7), Heart (RPKM 470.4) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (113103863..113109056)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111223508..111228671)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120901934..120903684)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart.
Title: A Novel Mitochondrial Complex of Aldosterone Synthase, Steroidogenic Acute Regulatory Protein, and Tom22 Synthesizes Aldosterone in the Rat Heart.
Analysis of signals that target rat TOM22 to the mitochondrial outer membrane and assembly into the TOM complex in cultured mammalian cells.
Title: Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

AW529762 (e-PCR)
- UniSTS:247452

RH141915 (e-PCR)
- UniSTS:223906

BI281592 (e-PCR)
- UniSTS:249506

RH127815 (e-PCR)
- UniSTS:211125

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mitochondrion targeting sequence binding	IEA Inferred from Electronic Annotation more info
enables mitochondrion targeting sequence binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial outer membrane translocase complex	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial outer membrane translocase complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial outer membrane translocase complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: mitochondrial import receptor subunit TOM22 homolog

Names: translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212514.2 → NP_997679.1 mitochondrial import receptor subunit TOM22 homolog

See identical proteins and their annotated locations for NP_997679.1

Status: PROVISIONAL

Source sequence(s)

BC098639

UniProtKB/Swiss-Prot

Q75Q41

UniProtKB/TrEMBL

A0A8I5ZQA0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

113103863..113109056

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078838.2 → XP_038934766.1 mitochondrial import receptor subunit TOM22 homolog isoform X1

UniProtKB/TrEMBL

A0A8L2Q9P3

Related

ENSRNOP00000019323.4