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Amigo2 adhesion molecule with Ig like domain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300186, updated on 9-Dec-2024

Summary

Official Symbol
Amigo2provided by RGD
Official Full Name
adhesion molecule with Ig like domain 2provided by RGD
Primary source
RGD:727911
See related
EnsemblRapid:ENSRNOG00000007032 AllianceGenome:RGD:727911
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ali1
Summary
Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of neuron apoptotic process. Predicted to be located in nucleus. Predicted to be active in membrane. Orthologous to human AMIGO2 (adhesion molecule with Ig like domain 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 296.5), Heart (RPKM 69.1) and 9 other tissues See more
Orthologs
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Genomic context

See Amigo2 in Genome Data Viewer
Location:
7q36
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (130270639..130273735, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (128391493..128394589, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (138704124..138707221, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479611 Neighboring gene uncharacterized LOC134479563 Neighboring gene PC-esterase domain containing 1B Neighboring gene uncharacterized LOC134479567 Neighboring gene basic transcription factor 3, pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in membrane  
located_in membrane  
located_in nucleus  
located_in plasma membrane PubMed 

General protein information

Preferred Names
amphoterin-induced protein 2
Names
AMIGO-2
alivin 1
amphoterin induced gene 2
transmembrane protein AMIGO2
transmembrane protein AMIGO2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182816.3NP_877968.3  amphoterin-induced protein 2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q7TNJ4, Q80ZD6
    UniProtKB/TrEMBL
    A0A0G2JSI9, A6KC34
    Conserved Domains (6) summary
    COG4886
    Location:53240
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:219231
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:5071
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00047
    Location:297367
    ig; Immunoglobulin domain
    pfam13855
    Location:93174
    LRR_8; Leucine rich repeat
    cd00096
    Location:304312
    Ig; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    130270639..130273735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263369.1XP_063119439.1  amphoterin-induced protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7TNJ4, Q80ZD6
    UniProtKB/TrEMBL
    A0A0G2JSI9, A6KC34
  2. XM_063263370.1XP_063119440.1  amphoterin-induced protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7TNJ4, Q80ZD6
    UniProtKB/TrEMBL
    A0A0G2JSI9, A6KC34
    Related
    ENSRNOP00000085327.1, ENSRNOT00000097759.2
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