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Lima1 LIM domain and actin binding 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300228, updated on 13-Apr-2024

Summary

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Official Symbol
Lima1provided by RGD
Official Full Name
LIM domain and actin binding 1provided by RGD
Primary source
RGD:1564050
See related
Ensembl:ENSRNOG00000059801 AllianceGenome:RGD:1564050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
eplin
Summary
Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; intestinal cholesterol absorption; and negative regulation of actin filament depolymerization. Predicted to be located in several cellular components, including brush border membrane; focal adhesion; and stress fiber. Predicted to be active in actin cytoskeleton and plasma membrane. Orthologous to human LIMA1 (LIM domain and actin binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 113.9), Spleen (RPKM 105.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lima1 in Genome Data Viewer
Location:
7q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132780556..132880343, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130901717..131001512, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141428113..141528447, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor COX14 Neighboring gene ceramide synthase 5 Neighboring gene uncharacterized LOC134479573 Neighboring gene uncharacterized LOC134479574 Neighboring gene uncharacterized LOC102549417 Neighboring gene family with sequence similarity 186 member A Neighboring gene La ribonucleoprotein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Extracellular signal-regulated kinase/mitogen-activated protein kinase regulates actin organization and cell motility by phosphorylating the actin cross-linking protein EPLIN. Han MY, et al. Mol Cell Biol, 2007 Dec. PMID 17875928, Free PMC Article
  2. EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. Maul RS, et al. J Cell Biol, 2003 Feb 3. PMID 12566430, Free PMC Article
  3. EPLIN, epithelial protein lost in neoplasm. Maul RS, et al. Oncogene, 1999 Dec 16. PMID 10618726
  4. Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells. Tsurumi H, et al. Kidney Int, 2014 Sep. PMID 24694988
  5. Characterization of mouse epithelial protein lost in neoplasm (EPLIN) and comparison of mammalian and zebrafish EPLIN. Maul RS, et al. Gene, 2001 Jan 10. PMID 11179679

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intestinal cholesterol absorption IEA
Inferred from Electronic Annotation
more info
  
involved_in intestinal cholesterol absorption ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ruffle organization IEA
Inferred from Electronic Annotation
more info
  
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in ruffle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
LIM domain and actin-binding protein 1
Names
epithelial protein lost in neoplasm

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191615.3 → NP_001178544.1  LIM domain and actin-binding protein 1

    See identical proteins and their annotated locations for NP_001178544.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    F1LR10, G3V8I6
    Related
    ENSRNOP00000072604.1, ENSRNOT00000091702.2
    Conserved Domains (1) summary
    cd09485
    Location:388 → 440
    LIM_Eplin_alpha_beta; The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    132780556..132880343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257354.5 → XP_006257416.1  LIM domain and actin-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AM55
    Related
    ENSRNOP00000096626.1
    Conserved Domains (1) summary
    cd09485
    Location:406 → 458
    LIM_Eplin_alpha_beta; The Lim domain of Epithelial Protein Lost in Neoplasm (Eplin)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LR10.2 GenPept UniProtKB/Swiss-Prot:F1LR10

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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