U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dip2b disco-interacting protein 2 homolog B [ Rattus norvegicus (Norway rat) ]

Gene ID: 300231, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Dip2bprovided by RGD
Official Full Name
disco-interacting protein 2 homolog Bprovided by RGD
Primary source
RGD:1305671
See related
Ensembl:ENSRNOG00000056106 AllianceGenome:RGD:1305671
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305671
Summary
Predicted to enable alpha-tubulin binding activity. Predicted to be involved in negative regulation of axon extension and positive regulation of peptidyl-lysine acetylation. Predicted to be located in several cellular components, including axon; dendrite; and perikaryon. Orthologous to human DIP2B (disco interacting protein 2 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 162.6), Lung (RPKM 154.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dip2b in Genome Data Viewer
Location:
7q36
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133053393..133231430)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131174575..131350417)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141702034..141878945)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549417 Neighboring gene family with sequence similarity 186 member A Neighboring gene La ribonucleoprotein 4 Neighboring gene uncharacterized LOC134479576 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 1, pseudogene 1 Neighboring gene uncharacterized LOC134479575 Neighboring gene activating transcription factor 1 Neighboring gene transmembrane serine protease 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterization of a novel luciferase-like protein in the human female reproductive tract. Khorram O, et al. J Clin Endocrinol Metab, 2004 Nov. PMID 15531550
  2. CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1. Winnepenninckx B, et al. Am J Hum Genet, 2007 Feb. PMID 17236128, Free PMC Article
  3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
disco-interacting protein 2 homolog B
Names
DIP2 disco-interacting protein 2 homolog B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    133053393..133231430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080376.2 → XP_038936304.1  disco-interacting protein 2 homolog B isoform X6

    Conserved Domains (2) summary
    cd05905
    Location:353 → 843
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain

  2. XM_063264367.1 → XP_063120437.1  disco-interacting protein 2 homolog B isoform X7

  3. XM_017595330.3 → XP_017450819.1  disco-interacting protein 2 homolog B isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY22, A6KCI1
    Related
    ENSRNOP00000070489.2

  4. XM_017595331.3 → XP_017450820.1  disco-interacting protein 2 homolog B isoform X2

    UniProtKB/TrEMBL
    A6KCI1

  5. XM_039080373.2 → XP_038936301.1  disco-interacting protein 2 homolog B isoform X3

    UniProtKB/TrEMBL
    A6KCI1
    Conserved Domains (2) summary
    cd05905
    Location:955 → 1520
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain

  6. XM_039080374.2 → XP_038936302.1  disco-interacting protein 2 homolog B isoform X4

    UniProtKB/TrEMBL
    A0A8I6ABD0, A6KCI1
    Related
    ENSRNOP00000089928.1
    Conserved Domains (2) summary
    cd05905
    Location:954 → 1519
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain

  7. XM_039080375.2 → XP_038936303.1  disco-interacting protein 2 homolog B isoform X5

    UniProtKB/TrEMBL
    A0A8I6ARX7, A6KCI1
    Related
    ENSRNOP00000095682.1
    Conserved Domains (2) summary
    cd05905
    Location:934 → 1499
    Dip2; Disco-interacting protein 2 (Dip2)
    pfam06464
    Location:14 → 130
    DMAP_binding; DMAP1-binding Domain

RNA

  1. XR_005487417.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous