Amot angiomotin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amotprovided by RGD
Official Full Name: angiomotinprovided by RGD
Primary source: RGD:1564027
See related: Ensembl:ENSRNOG00000007345 AllianceGenome:RGD:1564027
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564027
Summary: Predicted to enable angiostatin binding activity and signaling receptor activity. Predicted to be involved in several processes, including establishment of cell polarity involved in ameboidal cell migration; hippo signaling; and positive regulation of blood vessel endothelial cell migration. Predicted to act upstream of or within several processes, including gastrulation; negative regulation of GTPase activity; and vasculogenesis. Predicted to be located in several cellular components, including actin cytoskeleton; external side of plasma membrane; and ruffle. Predicted to be integral component of membrane. Predicted to be part of COP9 signalosome. Predicted to be active in several cellular components, including bicellular tight junction; cytoplasmic vesicle; and lamellipodium. Orthologous to human AMOT (angiomotin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 428.0), Kidney (RPKM 85.8) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (113778990..113837846, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (108982399..109041265, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (116751231..116810238, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells.
Title: Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells.
AMOT130/YAP mechanotransduction pathway plays a major role in topography-induced bone marrow mesenchymal stem cells osteoblastic differentiation.
Title: AMOT130/YAP pathway in topography-induced BMSC osteoblastic differentiation.
AMOT130 linking F-actin to YAP is involved in intervertebral disc degeneration
Title: AMOT130 linking F-actin to YAP is involved in intervertebral disc degeneration.
The AMOT-130 is essential for normal spine morphogenesis and identifies Lats1 as an upstream regulator in this process. Moreover, It findings may link AMOT-130 loss and the related spine defects to neurological disorders.
Title: The polarity protein Angiomotin p130 controls dendritic spine maturation.
This increased angiomotin p80/p130 ratio might then directly reflect the enhanced angiogenic ability of skeletal muscle in response to exercise training.
Title: Angiomotin p80/p130 ratio: a new indicator of exercise-induced angiogenic activity in skeletal muscles from obese and non-obese rats?

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables angiostatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration involved in gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity involved in ameboidal cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of cell polarity involved in ameboidal cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiomotin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

113778990..113837846 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257423.5 → XP_006257485.2 angiomotin isoform X1

UniProtKB/TrEMBL

A0A0G2JX94, A6KGA0

Conserved Domains (4) summary

COG1196
Location:417 → 664

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK05641
Location:1033 → 1066

PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated

PRK07764
Location:1032 → 1119

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam12240
Location:578 → 785

Angiomotin_C; Angiomotin C terminal
XM_006257420.5 → XP_006257482.2 angiomotin isoform X1

UniProtKB/TrEMBL

A0A0G2JX94, A6KGA0

Conserved Domains (4) summary

COG1196
Location:417 → 664

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK05641
Location:1033 → 1066

PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated

PRK07764
Location:1032 → 1119

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam12240
Location:578 → 785

Angiomotin_C; Angiomotin C terminal
XM_006257422.3 → XP_006257484.2 angiomotin isoform X1

UniProtKB/TrEMBL

A0A0G2JX94, A6KGA0

Conserved Domains (4) summary

COG1196
Location:417 → 664

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK05641
Location:1033 → 1066

PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated

PRK07764
Location:1032 → 1119

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam12240
Location:578 → 785

Angiomotin_C; Angiomotin C terminal
XM_006257421.3 → XP_006257483.2 angiomotin isoform X1

UniProtKB/TrEMBL

A0A0G2JX94, A6KGA0

Related

ENSRNOP00000070184.2

Conserved Domains (4) summary

COG1196
Location:417 → 664

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK05641
Location:1033 → 1066

PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated

PRK07764
Location:1032 → 1119

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam12240
Location:578 → 785

Angiomotin_C; Angiomotin C terminal
XM_063280350.1 → XP_063136420.1 angiomotin isoform X2
XM_006257424.5 → XP_006257486.2 angiomotin isoform X2

Conserved Domains (4) summary

COG1196
Location:28 → 275

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK05641
Location:644 → 677

PRK05641; putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated

PRK07764
Location:643 → 730

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam12240
Location:189 → 396

Angiomotin_C; Angiomotin C terminal