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L3mbtl2 L3MBTL histone methyl-lysine binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300320, updated on 13-Apr-2024

Summary

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Official Symbol
L3mbtl2provided by RGD
Official Full Name
L3MBTL histone methyl-lysine binding protein 2provided by RGD
Primary source
RGD:1308569
See related
Ensembl:ENSRNOG00000024743 AllianceGenome:RGD:1308569
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable methylated histone binding activity and promoter-specific chromatin binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Predicted to be active in nucleus. Orthologous to human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 125.7), Spleen (RPKM 98.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See L3mbtl2 in Genome Data Viewer
Location:
7q34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115066427..115087625)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113186303..113209706)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122896860..122918025)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene E1A binding protein p300 Neighboring gene ribosomal protein L35A like 1 Neighboring gene uncharacterized LOC120093698 Neighboring gene chondroadherin-like Neighboring gene RAN GTPase activating protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. Guo Y, et al. Nucleic Acids Res, 2009 Apr. PMID 19233876, Free PMC Article
  2. Proliferation-linked expression of the novel murine gene m4mbt encoding a nuclear zinc finger protein with four mbt domains. Markus J, et al. Gene, 2003 Nov 13. PMID 14597177
  3. L3MBTL1, a histone-methylation-dependent chromatin lock. Trojer P, et al. Cell, 2007 Jun 1. PMID 17540172
  4. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Qin J, et al. Cell Stem Cell, 2012 Sep 7. PMID 22770845, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124862

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ectoderm development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lethal(3)malignant brain tumor-like protein 2
Names
L3MBTL2 polycomb repressive complex 1 subunit
l(3)mbt-like 2 protein
l(3)mbt-like protein 2
lethal(3)malignant brain tumor-like 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033695.2 → NP_001028867.1  lethal(3)malignant brain tumor-like protein 2

    See identical proteins and their annotated locations for NP_001028867.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q3MIF2
    UniProtKB/TrEMBL
    A6HT06, A6HT07
    Related
    ENSRNOP00000031908.5, ENSRNOT00000034998.7
    Conserved Domains (2) summary
    smart00561
    Location:511 → 604
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:433 → 504
    MBT; mbt repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115066427..115087625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765711.4 → XP_008763933.1  lethal(3)malignant brain tumor-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A6HT07
    Conserved Domains (2) summary
    smart00561
    Location:511 → 604
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:433 → 504
    MBT; mbt repeat

  2. XM_017594794.3 → XP_017450283.1  lethal(3)malignant brain tumor-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HT07
    Conserved Domains (2) summary
    smart00561
    Location:420 → 513
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:342 → 413
    MBT; mbt repeat

  3. XM_039078957.2 → XP_038934885.1  lethal(3)malignant brain tumor-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HT07
    Conserved Domains (2) summary
    smart00561
    Location:420 → 513
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam02820
    Location:342 → 413
    MBT; mbt repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MIF2.1 GenPept UniProtKB/Swiss-Prot:Q3MIF2

Gene LinkOut

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