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Esam endothelial cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 300519, updated on 5-Mar-2024

Summary

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Official Symbol
Esamprovided by RGD
Official Full Name
endothelial cell adhesion moleculeprovided by RGD
Primary source
RGD:1303286
See related
Ensembl:ENSRNOG00000033217 AllianceGenome:RGD:1303286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in bicellular tight junction assembly; cellular protein localization; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in adherens junction; bicellular tight junction; and plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human ESAM (endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 460.5), Heart (RPKM 196.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Esam in Genome Data Viewer
Location:
8q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45426985..45437976)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (37238228..37249217)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39997875..40008802)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene roundabout guidance receptor 4 Neighboring gene roundabout guidance receptor 3 Neighboring gene uncharacterized LOC102549473 Neighboring gene Myb/SANT DNA binding domain containing 2 Neighboring gene V-set and immunoglobulin domain containing 2 Neighboring gene neurogranin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. Nasdala I, et al. J Biol Chem, 2002 May 3. PMID 11847224
  2. Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. Hirata Ki, et al. J Biol Chem, 2001 May 11. PMID 11279107
  3. Interaction of endothelial cell-selective adhesion molecule and MAGI-1 promotes mature cell-cell adhesion via activation of RhoA. Kimura R, et al. Genes Cells, 2010 Apr 1. PMID 20298433
  4. Platelet endothelial cell adhesion molecule-1 (PECAM1) plays a critical role in the maintenance of human vascular endothelial barrier function. Ren Q, et al. Cell Biochem Funct, 2015 Dec. PMID 26607202
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94065

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endothelial cell-selective adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004245.1 → NP_001004245.1  endothelial cell-selective adhesion molecule precursor

    See identical proteins and their annotated locations for NP_001004245.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079093
    UniProtKB/Swiss-Prot
    Q6AYD4
    UniProtKB/TrEMBL
    A6KRK8
    Related
    ENSRNOP00000051485.2, ENSRNOT00000050609.5
    Conserved Domains (3) summary
    smart00408
    Location:170 → 234
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:169 → 244
    IG_like; Immunoglobulin like
    pfam07686
    Location:42 → 153
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    45426985..45437976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265075.1 → XP_063121145.1  endothelial cell-selective adhesion molecule isoform X2

  2. XM_063265074.1 → XP_063121144.1  endothelial cell-selective adhesion molecule isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYD4.1 GenPept UniProtKB/Swiss-Prot:Q6AYD4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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