Meltf melanotransferrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Meltfprovided by MGI
Official Full Name: melanotransferrinprovided by MGI
Primary source: MGI:MGI:1353421
See related: Ensembl:ENSMUSG00000022780 AllianceGenome:MGI:1353421
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTf; Mfi2; CD228
Summary: Predicted to enable iron ion binding activity. Predicted to be involved in several processes, including negative regulation of substrate adhesion-dependent cell spreading; positive regulation of extracellular matrix disassembly; and positive regulation of plasminogen activation. Predicted to act upstream of or within ion transport and iron ion homeostasis. Predicted to be located in cell surface. Predicted to be anchored component of plasma membrane. Predicted to be active in endosome; extracellular space; and plasma membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; integumental system; and sensory organ. Orthologous to human MELTF (melanotransferrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 6.3), testis adult (RPKM 4.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B2; 16 22.4 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (31697449..31717838)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (31878629..31899020)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

melanotransferrin has a role in cell proliferation and tumorigenesis
Title: The function of melanotransferrin: a role in melanoma cell proliferation and tumorigenesis.
Iron indices, tissue levels, hematology, and serum chemistry parameters demonstrated no differences between metallototransferrin deficient and wild-type mice, suggesting MTf was not essential for iron metabolism.
Title: Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo.
MTf represents the first identification of a plant lectin receptor involved in cell-shape changes and the differentiation of animal cells
Title: Anti-membrane-bound transferrin-like protein antibodies induce cell-shape change and chondrocyte differentiation in the presence or absence of concanavalin A.
The distribution of MTf and its splice variants may provide clues to their possible biological roles in melanoma and other tumors.
Title: Examination of the distribution of the transferrin homologue, melanotransferrin (tumour antigen p97), in mouse and human.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Mfi2 (e-PCR), detects polymorphism
- UniSTS:470542

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: melanotransferrin

Names: antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; membrane-bound transferrin-like protein p97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013900.2 → NP_038928.1 melanotransferrin precursor

See identical proteins and their annotated locations for NP_038928.1

Status: PROVISIONAL

Source sequence(s)

AC129214

Consensus CDS

CCDS28108.1

UniProtKB/Swiss-Prot

Q9R0R1

UniProtKB/TrEMBL

Q544J8

Related

ENSMUSP00000023464.6, ENSMUST00000023464.6

Conserved Domains (4) summary

smart00094
Location:367 → 704

TR_FER; Transferrin

cd13529
Location:23 → 355

PBP2_transferrin; Transferrin family of the type 2 periplasmic-binding protein superfamily

pfam00405
Location:23 → 357

Transferrin; Transferrin

cl21456
Location:367 → 701

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

31697449..31717838

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522232.5 → XP_006522295.1 melanotransferrin isoform X1

Conserved Domains (2) summary

smart00094
Location:387 → 724

TR_FER; Transferrin

pfam00405
Location:23 → 377

Transferrin