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Arih1 ariadne RBR E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300756, updated on 3-Apr-2024

Summary

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Official Symbol
Arih1provided by RGD
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 1provided by RGD
Primary source
RGD:1308131
See related
Ensembl:ENSRNOG00000009887 AllianceGenome:RGD:1308131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in Lewy body and nuclear body. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 246.2), Adrenal (RPKM 225.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (68673199..68775648, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (59777378..59879762, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64166359..64268555, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ADP-dependent glucokinase Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene ribosomal protein L13, pseudogene 16 Neighboring gene cyclin-dependent kinases regulatory subunit 2-like Neighboring gene small nucleolar RNA SNORA40 Neighboring gene transmembrane protein 202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies. Elmehdawi F, et al. Exp Cell Res, 2013 Feb 1. PMID 23059369
  2. Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism. Duda DM, et al. Structure, 2013 Jun 4. PMID 23707686, Free PMC Article
  3. Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING. Capili AD, et al. J Mol Biol, 2004 Jul 23. PMID 15236971
  4. The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies. Parelkar SS, et al. J Mol Neurosci, 2012 Jan. PMID 21590270
  5. Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP. Tan NG, et al. FEBS Lett, 2003 Nov 20. PMID 14623119

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
NOT part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in Lewy body ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ARIH1
Names
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1
NP_001013126.2
XP_063121197.1
XP_063121198.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013108.3 → NP_001013126.2  E3 ubiquitin-protein ligase ARIH1

    See identical proteins and their annotated locations for NP_001013126.2

    Status: VALIDATED

    Source sequence(s)
    AW141789, BC083881, CA339823, CK478034, CN544531, CV126532, DN956151, DV714248, DY312590
    UniProtKB/TrEMBL
    D3ZXL1
    Related
    ENSRNOP00000083846.1, ENSRNOT00000118605.1
    Conserved Domains (3) summary
    smart00647
    Location:255 → 315
    IBR; In Between Ring fingers
    cd16626
    Location:183 → 240
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:337 → 377
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    68673199..68775648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265127.1 → XP_063121197.1  E3 ubiquitin-protein ligase ARIH1 isoform X1

  2. XM_063265128.1 → XP_063121198.1  E3 ubiquitin-protein ligase ARIH1 isoform X2

    UniProtKB/TrEMBL
    Q5XI15
Nucleotide Protein Strain
Heading Accession and Version

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