U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gramd2a GRAM domain containing 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 300761, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gramd2aprovided by RGD
Official Full Name
GRAM domain containing 2Aprovided by RGD
Primary source
RGD:1564007
See related
Ensembl:ENSRNOG00000025979 AllianceGenome:RGD:1564007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gramd2; RGD1564007
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and regulation of store-operated calcium entry. Predicted to be integral component of membrane. Predicted to be active in organelle membrane contact site. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. Orthologous to human GRAMD2A (GRAM domain containing 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 68.8) and Heart (RPKM 5.6) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gramd2a in Genome Data Viewer
Location:
8q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (68975529..69013575)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (60079744..60117788)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64503058..64539149)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 6 Neighboring gene U4 spliceosomal RNA Neighboring gene pyruvate kinase M1/2 Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene myosin IXA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. Besprozvannaya M, et al. Elife, 2018 Feb 22. PMID 29469807, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum-plasma membrane tethering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum-plasma membrane tethering ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in organelle membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GRAM domain-containing protein 2A
Names
GRAM domain containing 2
GRAM domain-containing protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399257.1 → NP_001386186.1  GRAM domain-containing protein 2A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZSZ0, A6J534
    Related
    ENSRNOP00000081651.1, ENSRNOT00000117011.1
    Conserved Domains (1) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    68975529..69013575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243199.5 → XP_006243261.1  GRAM domain-containing protein 2A isoform X4

    See identical proteins and their annotated locations for XP_006243261.1

    UniProtKB/TrEMBL
    D3ZIZ1
    Related
    ENSRNOP00000032874.6
    Conserved Domains (1) summary
    cd13220
    Location:84 → 177
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  2. XM_017596044.3 → XP_017451533.1  GRAM domain-containing protein 2A isoform X3

    Conserved Domains (1) summary
    cd13220
    Location:101 → 194
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  3. XM_017596047.3 → XP_017451536.1  GRAM domain-containing protein 2A isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZSZ0, A6J534
    Conserved Domains (1) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  4. XM_063265141.1 → XP_063121211.1  GRAM domain-containing protein 2A isoform X3

  5. XM_039082424.2 → XP_038938352.1  GRAM domain-containing protein 2A isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZSZ0, A6J534
    Conserved Domains (1) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  6. XM_039082422.2 → XP_038938350.1  GRAM domain-containing protein 2A isoform X2

    Conserved Domains (1) summary
    cd13220
    Location:143 → 236
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  7. XM_006243197.5 → XP_006243259.1  GRAM domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_006243259.1

    Conserved Domains (1) summary
    cd13220
    Location:143 → 236
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  8. XM_039082426.2 → XP_038938354.1  GRAM domain-containing protein 2A isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZSZ0, A6J534
    Conserved Domains (1) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  9. XM_006243201.5 → XP_006243263.1  GRAM domain-containing protein 2A isoform X5

    See identical proteins and their annotated locations for XP_006243263.1

    UniProtKB/TrEMBL
    A0A8I5ZSZ0, A6J534
    Conserved Domains (1) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  10. XM_217153.10 → XP_217153.5  GRAM domain-containing protein 2A isoform X5

    See identical proteins and their annotated locations for XP_217153.5

    UniProtKB/TrEMBL
    A0A8I5ZSZ0, A6J534
    Conserved Domains (1) summary
    cd13220
    Location:67 → 160
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools