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Hemk1 HemK methyltransferase family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300989, updated on 2-May-2024

Summary

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Official Symbol
Hemk1provided by RGD
Official Full Name
HemK methyltransferase family member 1provided by RGD
Primary source
RGD:1308293
See related
Ensembl:ENSRNOG00000015458 AllianceGenome:RGD:1308293
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308293
Summary
Predicted to enable nucleic acid binding activity; protein methyltransferase activity; and protein-(glutamine-N5) methyltransferase activity. Predicted to be involved in protein methylation. Orthologous to human HEMK1 (HemK methyltransferase family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 40.2), Kidney (RPKM 31.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hemk1 in Genome Data Viewer
Location:
8q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (116878317..116889342, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107999658..108010732, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116081858..116092872, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene cytokine inducible SH2-containing protein Neighboring gene similar to human chromosome 3 open reading frame 18 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene uncharacterized LOC134480230

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-(glutamine-N5) methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MTRF1L release factor glutamine methyltransferase
NP_001100323.1
XP_006243790.1
XP_006243791.1
XP_006243792.1
XP_038937143.1
XP_038937144.1
XP_063121308.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106853.1 → NP_001100323.1  MTRF1L release factor glutamine methyltransferase

    See identical proteins and their annotated locations for NP_001100323.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A0A8I6ADD7, A6I2W7, B1WBZ2, F7F513
    Related
    ENSRNOP00000020781.4, ENSRNOT00000020781.7
    Conserved Domains (2) summary
    TIGR03534
    Location:64 → 333
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    cl17173
    Location:91 → 300
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    116878317..116889342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243730.5 → XP_006243792.1  MTRF1L release factor glutamine methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006243792.1

    UniProtKB/TrEMBL
    A0A8I6ADD7, A6I2W7, B1WBZ2, F7F513
    Conserved Domains (2) summary
    TIGR03534
    Location:64 → 333
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    cl17173
    Location:91 → 300
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_006243729.5 → XP_006243791.1  MTRF1L release factor glutamine methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006243791.1

    UniProtKB/TrEMBL
    A0A8I6ADD7, A6I2W7, B1WBZ2, F7F513
    Conserved Domains (2) summary
    TIGR03534
    Location:64 → 333
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    cl17173
    Location:91 → 300
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_006243728.4 → XP_006243790.1  MTRF1L release factor glutamine methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006243790.1

    UniProtKB/TrEMBL
    A0A8I6ADD7, A6I2W7, B1WBZ2, F7F513
    Conserved Domains (2) summary
    TIGR03534
    Location:64 → 333
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    cl17173
    Location:91 → 300
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_039081215.2 → XP_038937143.1  MTRF1L release factor glutamine methyltransferase isoform X2

    Conserved Domains (1) summary
    TIGR03534
    Location:1 → 225
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  5. XM_039081216.1 → XP_038937144.1  MTRF1L release factor glutamine methyltransferase isoform X2

    Conserved Domains (1) summary
    TIGR03534
    Location:1 → 225
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  6. XM_063265238.1 → XP_063121308.1  MTRF1L release factor glutamine methyltransferase isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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