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Susd5 sushi domain containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301039, updated on 13-Apr-2024

Summary

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Official Symbol
Susd5provided by RGD
Official Full Name
sushi domain containing 5provided by RGD
Primary source
RGD:1561132
See related
Ensembl:ENSRNOG00000026951 AllianceGenome:RGD:1561132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561132
Summary
Predicted to enable hyaluronic acid binding activity. Predicted to be involved in Notch signaling pathway. Predicted to be integral component of membrane. Orthologous to human SUSD5 (sushi domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 36.4), Muscle (RPKM 27.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Susd5 in Genome Data Viewer
Location:
8q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (122874968..122914327)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (113996771..114036133)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (122331489..122370684)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene upstream binding protein 1 Neighboring gene F-box and leucine-rich repeat protein 2 Neighboring gene COP9 signalosome subunit 7B, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480241 Neighboring gene cartilage associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Fouillade C, et al. Arterioscler Thromb Vasc Biol, 2013 Jan. PMID 23117660, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sushi domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399281.1 → NP_001386210.1  sushi domain-containing protein 5 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I3N1, D3ZSC1
    Related
    ENSRNOP00000028675.4, ENSRNOT00000028675.5
    Conserved Domains (2) summary
    PHA03292
    Location:437 → 587
    PHA03292; envelope glycoprotein I; Provisional
    cl02612
    Location:35 → 129
    Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    122874968..122914327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766656.4 → XP_008764878.1  sushi domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_008764878.1

    Conserved Domains (1) summary
    cl02612
    Location:35 → 129
    Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...

  2. XM_039082675.1 → XP_038938603.1  sushi domain-containing protein 5 isoform X2

    Conserved Domains (1) summary
    PHA03292
    Location:243 → 393
    PHA03292; envelope glycoprotein I; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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