Acer1 alkaline ceramidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acer1provided by RGD
Official Full Name: alkaline ceramidase 1provided by RGD
Primary source: RGD:1588582
See related: Ensembl:ENSRNOG00000047368 AllianceGenome:RGD:1588582
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Asah3
Summary: Predicted to enable dihydroceramidase activity. Predicted to be involved in several processes, including regulation of water loss via skin; skin development; and sphingosine biosynthetic process. Predicted to act upstream of or within ceramide catabolic process and regulation of lipid metabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human ACER1 (alkaline ceramidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 5.6), Testes (RPKM 3.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (1881361..1911439, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (1794340..1824432, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (10061978..10093588)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	ISO Inferred from Sequence Orthology more info
enables ceramidase activity	IEA Inferred from Electronic Annotation more info
enables dihydroceramidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydroceramidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in ceramide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in epidermis development	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to alkaline pH	ISO Inferred from Sequence Orthology more info
involved_in sebaceous gland development	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sphingolipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sphingosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alkaline ceramidase 1

Names: N-acylsphingosine amidohydrolase (alkaline ceramidase) 3

NP_001100345.1

EC 3.5.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.