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Lonrf2 LON peptidase N-terminal domain and ring finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301361, updated on 5-Mar-2024

Summary

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Official Symbol
Lonrf2provided by RGD
Official Full Name
LON peptidase N-terminal domain and ring finger 2provided by RGD
Primary source
RGD:1562137
See related
Ensembl:ENSRNOG00000023312 AllianceGenome:RGD:1562137
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562137
Summary
Predicted to enable metal ion binding activity. Orthologous to human LONRF2 (LON peptidase N-terminal domain and ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 358.8), Adrenal (RPKM 49.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lonrf2 in Genome Data Viewer
Location:
9q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (48524962..48566353, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (41033125..41070551, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (45468001..45506448, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ALF transcription elongation factor 3 Neighboring gene histidine-rich glycoprotein-like Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134480286 Neighboring gene uncharacterized LOC134480359 Neighboring gene carbohydrate sulfotransferase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LON peptidase N-terminal domain and RING finger protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    48524962..48566353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244869.5 → XP_006244931.1  LON peptidase N-terminal domain and RING finger protein 2

    See identical proteins and their annotated locations for XP_006244931.1

    UniProtKB/TrEMBL
    D3ZX48
    Related
    ENSRNOP00000037315.5
    Conserved Domains (5) summary
    cd00162
    Location:447 → 486
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:527 → 732
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:223 → 253
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:537 → 737
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13432
    Location:25 → 90
    TPR_16; Tetratricopeptide repeat
Nucleotide Protein Strain
Heading Accession and Version

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