Il18r1 interleukin 18 receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il18r1provided by RGD
Official Full Name: interleukin 18 receptor 1provided by RGD
Primary source: RGD:1308589
See related: Ensembl:ENSRNOG00000015027 AllianceGenome:RGD:1308589
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable interleukin-18 binding activity and interleukin-18 receptor activity. Predicted to be involved in several processes, including interleukin-18-mediated signaling pathway; negative regulation of cold-induced thermogenesis; and positive regulation of cytokine production. Predicted to act upstream of or within T-helper 1 cell differentiation; natural killer cell activation; and positive regulation of NIK/NF-kappaB signaling. Predicted to be part of interleukin-18 receptor complex. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL18R1 (interleukin 18 receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 29.2), Thymus (RPKM 20.1) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (50223274..50257370)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (42727416..42760971)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (47184404..47217403)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine.
Title: Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine.
The aim of this study was to evaluate the constitutive expression of IL-18 and its receptors (IL-18Ralpha and IL-18Rbeta) in intestinal epithelial cells (IEC) stimulated by tumor necrosis factor-alpha and interferon-gamma.
Title: Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-18 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-18 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-18 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-18 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in interleukin-18-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of T-helper 1 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of interleukin-18 receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-18 receptor 1

Names: IL18Ralpha2

NP_001100375.1

EC 3.2.2.6

XP_063123001.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106905.2 → NP_001100375.1 interleukin-18 receptor 1 precursor

See identical proteins and their annotated locations for NP_001100375.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6A1C2, A6INN8

Related

ENSRNOP00000085021.1, ENSRNOT00000095201.1

Conserved Domains (4) summary

smart00255
Location:370 → 519

TIR; Toll - interleukin 1 - resistance

pfam13895
Location:20 → 106

Ig_2; Immunoglobulin domain

cd00096
Location:160 → 162

Ig; Ig strand C' [structural motif]

cl11960
Location:156 → 205

Ig; Immunoglobulin domain