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Orc2 origin recognition complex, subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301430, updated on 11-Apr-2024

Summary

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Official Symbol
Orc2provided by RGD
Official Full Name
origin recognition complex, subunit 2provided by RGD
Primary source
RGD:1311844
See related
Ensembl:ENSRNOG00000012558 AllianceGenome:RGD:1311844
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Orc2l
Summary
Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication. Predicted to be located in centrosome; heterochromatin; and nucleoplasm. Predicted to be part of inner kinetochore and nuclear origin of replication recognition complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human ORC2 (origin recognition complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 143.7), Spleen (RPKM 114.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q31
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67496097..67532548, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60001631..60038301, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65350630..65387293, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 3 Neighboring gene U2 spliceosomal RNA Neighboring gene NGG1 interacting factor 3 like 1 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene BAF nuclear assembly factor 1, pseudogene 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. Prasanth SG, et al. EMBO J, 2004 Jul 7. PMID 15215892, Free PMC Article
  2. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Dannenberg JH, et al. Genes Dev, 2005 Jul 1. PMID 15998811, Free PMC Article
  3. Cyclin E ablation in the mouse. Geng Y, et al. Cell, 2003 Aug 22. PMID 12941272
  4. ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973
  5. A WD-repeat protein stabilizes ORC binding to chromatin. Shen Z, et al. Mol Cell, 2010 Oct 8. PMID 20932478, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA replication origin binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012003.1 → NP_001012003.1  origin recognition complex subunit 2

    See identical proteins and their annotated locations for NP_001012003.1

    Status: PROVISIONAL

    Source sequence(s)
    AB164704
    UniProtKB/Swiss-Prot
    Q75PQ8
    UniProtKB/TrEMBL
    A0A8I5ZNQ6, A6IP72
    Conserved Domains (1) summary
    pfam04084
    Location:254 → 560
    ORC2; Origin recognition complex subunit 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    67496097..67532548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244956.5 → XP_006245018.1  origin recognition complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006245018.1

    UniProtKB/Swiss-Prot
    Q75PQ8
    UniProtKB/TrEMBL
    A0A8I5ZNQ6, A6IP72
    Related
    ENSRNOP00000042867.3
    Conserved Domains (1) summary
    pfam04084
    Location:254 → 560
    ORC2; Origin recognition complex subunit 2

  2. XM_017596360.3 → XP_017451849.1  origin recognition complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNQ6
    Conserved Domains (1) summary
    pfam04084
    Location:224 → 530
    ORC2; Origin recognition complex subunit 2

  3. XM_063266944.1 → XP_063123014.1  origin recognition complex subunit 2 isoform X2

  4. XM_039083303.2 → XP_038939231.1  origin recognition complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q75PQ8
    UniProtKB/TrEMBL
    A0A8I5ZNQ6, A6IP72
    Conserved Domains (1) summary
    pfam04084
    Location:254 → 560
    ORC2; Origin recognition complex subunit 2

  5. XM_039083305.2 → XP_038939233.1  origin recognition complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q75PQ8
    UniProtKB/TrEMBL
    A0A8I5ZNQ6, A6IP72
    Related
    ENSRNOP00000079927.1
    Conserved Domains (1) summary
    pfam04084
    Location:254 → 560
    ORC2; Origin recognition complex subunit 2

  6. XM_039083302.2 → XP_038939230.1  origin recognition complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q75PQ8
    UniProtKB/TrEMBL
    A0A8I5ZNQ6, A6IP72
    Conserved Domains (1) summary
    pfam04084
    Location:254 → 560
    ORC2; Origin recognition complex subunit 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q75PQ8.1 GenPept UniProtKB/Swiss-Prot:Q75PQ8

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