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Ppil3 peptidylprolyl isomerase like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301432, updated on 2-May-2024

Summary

Official Symbol
Ppil3provided by RGD
Official Full Name
peptidylprolyl isomerase like 3provided by RGD
Primary source
RGD:631415
See related
Ensembl:ENSRNOG00000013636 AllianceGenome:RGD:631415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cyp10l
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PPIL3 (peptidylprolyl isomerase like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 109.1), Muscle (RPKM 81.4) and 9 other tissues See more
Orthologs
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Genomic context

See Ppil3 in Genome Data Viewer
Location:
9q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67460594..67474325, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59966405..59980147, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65315407..65329145, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene CDC-like kinase 1 Neighboring gene uncharacterized LOC134480578 Neighboring gene U2 spliceosomal RNA Neighboring gene NGG1 interacting factor 3 like 1 Neighboring gene origin recognition complex, subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Clone Names

  • MGC105285

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase-like 3
Names
PPIase
cyclophilin-like protein 3
cyclophilin-like protein PPIL3
peptidylprolyl cis-trans isomerase-like protein 3
peptidylprolyl isomerase (cyclophilin)-like 3
rotamase PPIL3
NP_783638.1
XP_006245026.1
XP_017451851.1
XP_038939239.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175707.3NP_783638.1  peptidyl-prolyl cis-trans isomerase-like 3

    See identical proteins and their annotated locations for NP_783638.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087645
    UniProtKB/Swiss-Prot
    Q812D3
    UniProtKB/TrEMBL
    A0A8L2Q9D4, A6IP66
    Related
    ENSRNOP00000079425.1, ENSRNOT00000103798.1
    Conserved Domains (1) summary
    cd01928
    Location:1154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    67460594..67474325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596362.3XP_017451851.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    UniProtKB/Swiss-Prot
    Q812D3
    UniProtKB/TrEMBL
    A0A8L2Q9D4, A6IP66
    Conserved Domains (1) summary
    cd01928
    Location:1154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
  2. XM_006244964.5XP_006245026.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

    See identical proteins and their annotated locations for XP_006245026.1

    UniProtKB/Swiss-Prot
    Q812D3
    UniProtKB/TrEMBL
    A0A8L2Q9D4, A6IP66
    Conserved Domains (1) summary
    cd01928
    Location:1154
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
  3. XM_039083311.2XP_038939239.1  peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

    Conserved Domains (1) summary
    cd01928
    Location:1120
    Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...