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Tns1 tensin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301509, updated on 2-May-2024

Summary

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Official Symbol
Tns1provided by RGD
Official Full Name
tensin 1provided by RGD
Primary source
RGD:68427
See related
Ensembl:ENSRNOG00000014182 AllianceGenome:RGD:68427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tns
Summary
Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within cell-substrate junction assembly and fibroblast migration. Predicted to be located in focal adhesion. Orthologous to human TNS1 (tensin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 927.0), Heart (RPKM 881.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tns1 in Genome Data Viewer
Location:
9q33
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (82941068..83152007, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (75491886..75702853, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81190192..81401020, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134480593 Neighboring gene uncharacterized LOC134480594 Neighboring gene ribosomal protein S21, pseudogene 7 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Chen H, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11792844, Free PMC Article
  2. Progressive kidney degeneration in mice lacking tensin. Lo SH, et al. J Cell Biol, 1997 Mar 24. PMID 9087448, Free PMC Article
  3. Molecular characterization of human tensin. Chen H, et al. Biochem J, 2000 Oct 15. PMID 11023826, Free PMC Article
  4. Genes for tensin, villin and desmin are linked on mouse chromosome 1. Jankowski SA, et al. Mamm Genome, 1995 Oct. PMID 8563175
  5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell-substrate junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in fibroblast migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell-substrate junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tensin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191810.3 → NP_001178739.1  tensin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5Y194
    Related
    ENSRNOP00000091650.1, ENSRNOT00000097211.1
    Conserved Domains (5) summary
    cd09927
    Location:1633 → 1748
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:250 → 365
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:75 → 108
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:1770 → 1903
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:352 → 478
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    82941068..83152007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083336.2 → XP_038939264.1  tensin-1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5Y194, A0A8I6A4G0
    Related
    ENSRNOP00000087478.1
    Conserved Domains (6) summary
    cd09927
    Location:1612 → 1727
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1053 → 1582
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1749 → 1882
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:352 → 478
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd20888
    Location:57 → 112
    C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
    cl28904
    Location:187 → 345
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_063266966.1 → XP_063123036.1  tensin-1 isoform X5

  3. XM_063266965.1 → XP_063123035.1  tensin-1 isoform X4

  4. XM_039083330.2 → XP_038939258.1  tensin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y194
    Conserved Domains (6) summary
    cd09927
    Location:1661 → 1776
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1091 → 1643
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1798 → 1931
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:352 → 478
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd20888
    Location:57 → 112
    C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
    cl28904
    Location:187 → 345
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. XM_039083335.2 → XP_038939263.1  tensin-1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y194
    Related
    ENSRNOP00000077508.1
    Conserved Domains (6) summary
    cd09927
    Location:1620 → 1735
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:1045 → 1602
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1757 → 1890
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:311 → 437
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd20888
    Location:16 → 71
    C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
    cl28904
    Location:146 → 304
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  6. XM_039083352.2 → XP_038939280.1  tensin-1 isoform X10

    UniProtKB/TrEMBL
    F1LN42
    Related
    ENSRNOP00000032812.6
    Conserved Domains (5) summary
    cd09927
    Location:1511 → 1626
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:941 → 1493
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1648 → 1781
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:202 → 328
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:37 → 195
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  7. XM_039083349.2 → XP_038939277.1  tensin-1 isoform X10

    UniProtKB/TrEMBL
    F1LN42
    Conserved Domains (5) summary
    cd09927
    Location:1511 → 1626
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:941 → 1493
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1648 → 1781
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:202 → 328
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:37 → 195
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  8. XM_039083341.2 → XP_038939269.2  tensin-1 isoform X10

  9. XM_063266971.1 → XP_063123041.1  tensin-1 isoform X16

  10. XM_039083348.2 → XP_038939276.2  tensin-1 isoform X15

  11. XM_039083346.2 → XP_038939274.2  tensin-1 isoform X13

  12. XM_039083347.2 → XP_038939275.2  tensin-1 isoform X14

  13. XM_063266969.1 → XP_063123039.1  tensin-1 isoform X12

  14. XM_039083344.2 → XP_038939272.2  tensin-1 isoform X11

  15. XM_063266968.1 → XP_063123038.1  tensin-1 isoform X9

  16. XM_063266967.1 → XP_063123037.1  tensin-1 isoform X8

  17. XM_063266963.1 → XP_063123033.1  tensin-1 isoform X2

  18. XM_063266962.1 → XP_063123032.1  tensin-1 isoform X1

  19. XM_039083351.2 → XP_038939279.1  tensin-1 isoform X10

    UniProtKB/TrEMBL
    F1LN42
    Conserved Domains (5) summary
    cd09927
    Location:1511 → 1626
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:941 → 1493
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1648 → 1781
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:202 → 328
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:37 → 195
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  20. XM_039083350.2 → XP_038939278.1  tensin-1 isoform X10

    UniProtKB/TrEMBL
    F1LN42
    Conserved Domains (5) summary
    cd09927
    Location:1511 → 1626
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:941 → 1493
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1648 → 1781
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:202 → 328
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:37 → 195
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  21. XM_063266972.1 → XP_063123042.1  tensin-1 isoform X17

Nucleotide Protein Strain
Heading Accession and Version

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