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Sp110 SP110 nuclear body protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 301570, updated on 3-Apr-2024

Summary

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Official Symbol
Sp110provided by RGD
Official Full Name
SP110 nuclear body proteinprovided by RGD
Primary source
RGD:1310173
See related
Ensembl:ENSRNOG00000033747 AllianceGenome:RGD:1310173
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of apoptotic process and response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatic venoocclusive disease with immunodeficiency and tuberculosis. Orthologous to human SP110 (SP110 nuclear body protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 350.6), Thymus (RPKM 325.7) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Sp110 in Genome Data Viewer
Location:
9q35
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (93648574..93673476, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (86200503..86225355, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (92593909..92618867, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 16, member 14 Neighboring gene uncharacterized LOC120094727 Neighboring gene uncharacterized LOC134480599 Neighboring gene component of Sp100-rs Neighboring gene SP140 nuclear body protein Neighboring gene SP100 nuclear antigen Neighboring gene RIKEN cDNA A630001G21 gene like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ipr1 gene mediates innate immunity to tuberculosis. Pan H, et al. Nature, 2005 Apr 7. PMID 15815631, Free PMC Article
  2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124651

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sp110 nuclear body protein
Names
intracellular pathogen resistance protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034137.1 → NP_001029309.1  sp110 nuclear body protein

    See identical proteins and their annotated locations for NP_001029309.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105751
    UniProtKB/Swiss-Prot
    Q3KRF1
    UniProtKB/TrEMBL
    R9PXZ9
    Related
    ENSRNOP00000053828.5, ENSRNOT00000056995.5
    Conserved Domains (2) summary
    pfam01342
    Location:390 → 465
    SAND; SAND domain
    pfam03172
    Location:8 → 106
    HSR; HSR domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    93648574..93673476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267020.1 → XP_063123090.1  sp110 nuclear body protein isoform X1

    UniProtKB/Swiss-Prot
    Q3KRF1

  2. XM_039083401.2 → XP_038939329.1  sp110 nuclear body protein isoform X1

    UniProtKB/Swiss-Prot
    Q3KRF1
    UniProtKB/TrEMBL
    R9PXZ9
    Conserved Domains (2) summary
    pfam01342
    Location:390 → 465
    SAND; SAND domain
    pfam03172
    Location:8 → 106
    HSR; HSR domain

  3. XM_039083402.2 → XP_038939330.1  sp110 nuclear body protein isoform X1

    UniProtKB/Swiss-Prot
    Q3KRF1
    UniProtKB/TrEMBL
    R9PXZ9
    Conserved Domains (2) summary
    pfam01342
    Location:390 → 465
    SAND; SAND domain
    pfam03172
    Location:8 → 106
    HSR; HSR domain

  4. XM_039083404.2 → XP_038939332.1  sp110 nuclear body protein isoform X3

    UniProtKB/TrEMBL
    R9PXZ9
    Conserved Domains (2) summary
    pfam01342
    Location:336 → 411
    SAND; SAND domain
    pfam03172
    Location:8 → 106
    HSR; HSR domain

  5. XM_039083403.2 → XP_038939331.1  sp110 nuclear body protein isoform X2

    UniProtKB/TrEMBL
    R9PXZ9
    Conserved Domains (2) summary
    pfam01342
    Location:362 → 437
    SAND; SAND domain
    pfam03172
    Location:8 → 106
    HSR; HSR domain

  6. XM_063267021.1 → XP_063123091.1  sp110 nuclear body protein isoform X5

  7. XM_039083405.2 → XP_038939333.1  sp110 nuclear body protein isoform X4

    Conserved Domains (1) summary
    pfam01342
    Location:180 → 255
    SAND; SAND domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KRF1.1 GenPept UniProtKB/Swiss-Prot:Q3KRF1

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