Tert telomerase reverse transcriptase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tertprovided by RGD
Official Full Name: telomerase reverse transcriptaseprovided by RGD
Primary source: RGD:70494
See related: Ensembl:ENSRNOG00000025327 AllianceGenome:RGD:70494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including chaperone binding activity; nucleic acid binding activity; and nucleotidyltransferase activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of transdifferentiation; and positive regulation of vascular associated smooth muscle cell migration. Located in mitochondrion and nucleus. Used to study chronic kidney disease and transient cerebral ischemia. Biomarker of hepatocellular carcinoma and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase reverse transcriptase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 26.6), Thymus (RPKM 16.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31465766..31488650, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29637213..29659561, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (32250876..32275330, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage.
Title: Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage.
Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis.
Title: Butyrate-containing structured lipids act on HDAC4, HDAC6, DNA damage and telomerase activity during promotion of experimental hepatocarcinogenesis.
Autophagy, TERT, and mitochondrial dysfunction in hyperoxia.
Title: Autophagy, TERT, and mitochondrial dysfunction in hyperoxia.
Reactive oxygen species up-regulation inhibits TERT expression, suppresses TERT activity and facilitates premature ovarian failure.
Title: Protective effects ROS up-regulation on premature ovarian failure by suppressing ROS-TERT signal pathway.
Curcumin may be a good candidate to improve lifespan of rADSCs through promoting TERT gene expression.
Title: Curcumin Affects Adipose Tissue-Derived Mesenchymal Stem Cell Aging Through TERT Gene Expression.
TERT was expressed in the basilar membranes during the first postnatal week. In vitro, TERT expression in progenitor cells reached a maximum at day 4 after culture and decreased as the culture time prolonged or the cell passage number increased. These results led us to hypothesize that TERT may be involved in the development of the cochlea and in maintaining the proliferation ability of progenitor cells.
Title: Decreased expression of TERT correlated with postnatal cochlear development and proliferation reduction of cochlear progenitor cells.
Proliferation rate, telomerase activity, telomere length, and differentiation to cholinergic neuron-like cells (CNLCs) were observed to increase. Though, the expression level of telomerase reverse transcriptase gene increased, but CTC1 and TEN1 genes from Ctc1-Stn1-Ten1 complex encoding proteins with regulatory function significantly decreased
Title: Stimulation of cell proliferation by glutathione monoethyl ester in aged bone marrow stromal cells is associated with the assistance of TERT gene expression and telomerase activity.
Histone deacetylase inhibition induces TERT transcription and promoter activation. At the protein level in contrast, HDAC inhibition decreases TERT protein abundance through enhanced degradation, which decreases telomerase activity and induces senescence.
Title: Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition.
These findings suggest that cardiac telomerase activity may play an important role in the maintenance of normal cardiac function.
Title: Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts.
TERT is a genome-independent source of mature miRNA, and the changes in telomerase activity can significantly influence the level of miRNA in cardiomyocytes.
Title: Silencing of TERT decreases levels of miR-1, miR-21, miR-29a and miR-208a in cardiomyocytes.

Submit: New GeneRIF Correction See all GeneRIFs (37)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA-dependent RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables RNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables telomerase RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info
enables telomerase RNA reverse transcriptase activity	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase RNA reverse transcriptase activity	IEA Inferred from Electronic Annotation more info
enables telomerase RNA reverse transcriptase activity	ISO Inferred from Sequence Orthology more info
enables telomerase RNA reverse transcriptase activity	TAS Traceable Author Statement more info	PubMed
enables telomerase activity	ISO Inferred from Sequence Orthology more info
enables telomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables template-free RNA nucleotidyltransferase	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in RNA-templated DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in RNA-templated DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in RNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell proliferation	IDA Inferred from Direct Assay more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hair cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in siRNA processing	ISO Inferred from Sequence Orthology more info
involved_in siRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
part_of RNA-directed RNA polymerase complex	ISO Inferred from Sequence Orthology more info
part_of TERT-RMRP complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of telomerase catalytic core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of telomerase catalytic core complex	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: telomerase reverse transcriptase

Names: telomerase catalytic subunit

NP_445875.1

EC 2.7.7.49

XP_008756905.1

EC 2.7.7.49

XP_017444567.1

EC 2.7.7.49

XP_038965922.1

EC 2.7.7.49

XP_038965926.1

EC 2.7.7.49

XP_038965931.1

EC 2.7.7.49

XP_063144058.1

EC 2.7.7.49

XP_063144068.1

EC 2.7.7.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053423.2 → NP_445875.1 telomerase reverse transcriptase

See identical proteins and their annotated locations for NP_445875.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q1LZ57, Q4U0V7, Q673L3, Q673L5, Q673L6, Q80SU5

UniProtKB/TrEMBL

A0A8I6AEW6, A6JUX4

Related

ENSRNOP00000076971.1, ENSRNOT00000100559.1

Conserved Domains (2) summary

smart00975
Location:450 → 584

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain

cd01648
Location:816 → 929

TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

31465766..31488650 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287988.1 → XP_063144058.1 telomerase reverse transcriptase isoform X2
XM_017589078.3 → XP_017444567.1 telomerase reverse transcriptase isoform X4

UniProtKB/TrEMBL

A0A8I6AEW6
XM_063287998.1 → XP_063144068.1 telomerase reverse transcriptase isoform X3
XM_008758683.4 → XP_008756905.1 telomerase reverse transcriptase isoform X1

UniProtKB/TrEMBL

A0A8I6AEW6

Conserved Domains (2) summary

smart00975
Location:454 → 588

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain

cd01648
Location:820 → 933

TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
XM_039110003.2 → XP_038965931.1 telomerase reverse transcriptase isoform X7

Conserved Domains (2) summary

cd01648
Location:284 → 397

TERT; Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase ...

cl13446
Location:2 → 52

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
XM_039109994.2 → XP_038965922.1 telomerase reverse transcriptase isoform X5

Conserved Domains (1) summary

smart00975
Location:454 → 588

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
XM_039109998.2 → XP_038965926.1 telomerase reverse transcriptase isoform X6

Conserved Domains (1) summary

cl13446
Location:454 → 518

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain

RNA

XR_005504447.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001007019.1: Suppressed sequence

Description

NM_001007019.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript or protein.