Abcb7 ATP binding cassette subfamily B member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcb7provided by RGD
Official Full Name: ATP binding cassette subfamily B member 7provided by RGD
Primary source: RGD:1303086
See related: Ensembl:ENSRNOG00000002790 AllianceGenome:RGD:1303086
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ABC-type iron-sulfur cluster transporter activity and protein homodimerization activity. Involved in cellular iron ion homeostasis and negative regulation of reactive oxygen species biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Orthologous to human ABCB7 (ATP binding cassette subfamily B member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 163.4), Muscle (RPKM 149.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (73361296..73502464, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (69295598..69436775, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (75150511..75291950, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function.
Title: Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type iron-sulfur cluster transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type iron-sulfur cluster transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type iron-sulfur cluster transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in iron ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in iron ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in iron-sulfur cluster export from the mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster export from the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster export from the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of iron-sulfur cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of iron-sulfur cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: iron-sulfur clusters transporter ABCB7, mitochondrial

Names: ABC transporter 7 protein; ATP-binding cassette transporter 7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; ATP-binding cassette, sub-family B, member 7, mitochondrial; ATP-binding cassette, subfamily B (MDR/TAP), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212518.1 → NP_997683.1 iron-sulfur clusters transporter ABCB7, mitochondrial

See identical proteins and their annotated locations for NP_997683.1

Status: PROVISIONAL

Source sequence(s)

AJ621255

UniProtKB/Swiss-Prot

Q704E8

UniProtKB/TrEMBL

A0A0G2K866

Related

ENSRNOP00000074489.2, ENSRNOT00000083655.2

Conserved Domains (3) summary

cd03253
Location:472 → 708

ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C

COG5265
Location:210 → 705

ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]

pfam00664
Location:150 → 424

ABC_membrane; ABC transporter transmembrane region