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F8 coagulation factor VIII [ Rattus norvegicus (Norway rat) ]

Gene ID: 302470, updated on 13-Apr-2024

Summary

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Official Symbol
F8provided by RGD
Official Full Name
coagulation factor VIIIprovided by RGD
Primary source
RGD:727845
See related
Ensembl:ENSRNOG00000031197 AllianceGenome:RGD:727845
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Located in extracellular space. Used to study factor VIII deficiency; hemarthrosis; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 92.8), Heart (RPKM 64.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18p13
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (155237..187186)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (140848..172330)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (367862..399242, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex, subunit 3, pseudogene 7 Neighboring gene FUN14 domain containing 2 Neighboring gene uncharacterized LOC134482991 Neighboring gene mature T-cell proliferation 1 Neighboring gene C-X9-C motif containing 4 Neighboring gene uncharacterized LOC134482992 Neighboring gene myotubularin related protein 1 Neighboring gene zinc finger protein 91, pseudogene 2 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. Shi Q, et al. Blood Adv, 2020 Jan 14. PMID 31899798, Free PMC Article
  2. Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia. Manon-Jensen T, et al. J Thromb Haemost, 2016 Dec. PMID 27681457
  3. The F8(-/-) rat as a model of hemophilic arthropathy. Sørensen KR, et al. J Thromb Haemost, 2016 Jun. PMID 27060449
  4. A novel F8 -/- rat as a translational model of human hemophilia A. Nielsen LN, et al. J Thromb Haemost, 2014 Aug. PMID 24931420
  5. Sequence of the rat factor VIII cDNA. Watzka M, et al. Thromb Haemost, 2004 Jan. PMID 14691566

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of a F8(-/-) rat model of hemophilic arthropathy reveals that collagen turnover is altered
    Title: Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia.
  2. analysis of animal models for hemophilia A and the advantage of rats over mice in the factor VIII gene mutation model
    Title: WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A.
  3. Sequence of the rat factor VIII cDNA
    Title: Sequence of the rat factor VIII cDNA.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation, intrinsic pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood coagulation, intrinsic pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor VIII
Names
coagulation factor VIII, procoagulant component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183331.2 → NP_899160.2  coagulation factor VIII precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    D3ZEB1, Q7TN96
    Related
    ENSRNOP00000050792.5, ENSRNOT00000045926.5
    Conserved Domains (2) summary
    cd00057
    Location:2103 → 2251
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl19115
    Location:387 → 563
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    155237..187186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277282.1 → XP_063133352.1  coagulation factor VIII isoform X1

  2. XM_063277283.1 → XP_063133353.1  coagulation factor VIII isoform X2

  3. XM_039096756.2 → XP_038952684.1  coagulation factor VIII isoform X3

    UniProtKB/TrEMBL
    Q7TN96
    Conserved Domains (1) summary
    cl19115
    Location:387 → 563
    Cupredoxin; Cupredoxin superfamily

  4. XM_039096757.2 → XP_038952685.1  coagulation factor VIII isoform X4

    Conserved Domains (1) summary
    cl19115
    Location:387 → 563
    Cupredoxin; Cupredoxin superfamily

  5. XM_063277284.1 → XP_063133354.1  coagulation factor VIII isoform X5

  6. XM_063277285.1 → XP_063133355.1  coagulation factor VIII isoform X6

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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