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Mcts1 MCTS1, re-initiation and release factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 302500, updated on 5-Mar-2024

Summary

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Official Symbol
Mcts1provided by RGD
Official Full Name
MCTS1, re-initiation and release factorprovided by RGD
Primary source
RGD:1566390
See related
Ensembl:ENSRNOG00000002563 AllianceGenome:RGD:1566390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be involved in IRES-dependent viral translational initiation; formation of translation preinitiation complex; and ribosome disassembly. Predicted to be located in cytosol and plasma membrane. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human MCTS1 (MCTS1 re-initiation and release factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 102.1), Thymus (RPKM 99.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcts1 in Genome Data Viewer
Location:
Xq35
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (122215602..122228101)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (117350723..117362504)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (124894269..124906129)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ragulator complex protein LAMTOR5-like Neighboring gene uncharacterized LOC134484034 Neighboring gene cullin 4B Neighboring gene C1GALT1-specific chaperone 1 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury. Han J, et al. J Cell Mol Med, 2020 Apr. PMID 32160403, Free PMC Article
  2. Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. Skabkin MA, et al. Genes Dev, 2010 Aug 15. PMID 20713520, Free PMC Article
  3. Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, et al. Mol Cell Proteomics, 2007 May. PMID 16854843
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury.
    Title: Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112904

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in IRES-dependent viral translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of translation preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
malignant T-cell-amplified sequence 1
Names
MCT-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044237.1 → NP_001037702.1  malignant T-cell-amplified sequence 1

    See identical proteins and their annotated locations for NP_001037702.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098848
    UniProtKB/Swiss-Prot
    Q4G009
    UniProtKB/TrEMBL
    A0A8I6ADP8, A6JMK9
    Related
    ENSRNOP00000061717.1, ENSRNOT00000066677.2
    Conserved Domains (2) summary
    cd11609
    Location:5 → 81
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:81 → 176
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    122215602..122228101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257488.5 → XP_006257550.1  malignant T-cell-amplified sequence 1 isoform X1

    See identical proteins and their annotated locations for XP_006257550.1

    UniProtKB/TrEMBL
    A0A0G2K724, A0A8I6ADP8, A6JMK7
    Related
    ENSRNOP00000074032.1
    Conserved Domains (2) summary
    cd11609
    Location:4 → 80
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:80 → 175
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

  2. XM_039099623.2 → XP_038955551.1  malignant T-cell-amplified sequence 1 isoform X2

    UniProtKB/TrEMBL
    A6JMK8
    Conserved Domains (2) summary
    pfam17832
    Location:5 → 38
    Pre-PUA; Pre-PUA-like domain
    cd21155
    Location:29 → 124
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G009.1 GenPept UniProtKB/Swiss-Prot:Q4G009

Gene LinkOut

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