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Efhc2 EF-hand domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302507, updated on 5-Mar-2024

Summary

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Official Symbol
Efhc2provided by RGD
Official Full Name
EF-hand domain containing 2provided by RGD
Primary source
RGD:1563388
See related
Ensembl:ENSRNOG00000002986 AllianceGenome:RGD:1563388
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563388
Summary
Predicted to enable alpha-tubulin binding activity. Predicted to be involved in several processes, including cilium-dependent cell motility; mitotic cytokinesis; and mitotic spindle organization. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in ciliary basal body. Predicted to be active in axoneme and mitotic spindle. Predicted to colocalize with microtubule. Orthologous to human EFHC2 (EF-hand domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 63.6), Testes (RPKM 47.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (7943603..8144073)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (5360499..5564004)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (5825551..6026398)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1 pseudogene Neighboring gene uncharacterized LOC120099197 Neighboring gene proteasome 20S subunit alpha 2, pseudogene 2 Neighboring gene basic leucine zipper nuclear factor 1, pseudogene 1 Neighboring gene norrin cystine knot growth factor NDP

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EF-hand domain-containing family member C2
Names
EF-hand domain (C-terminal) containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106952.1 → NP_001100422.1  EF-hand domain-containing family member C2

    See identical proteins and their annotated locations for NP_001100422.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474009
    UniProtKB/TrEMBL
    A6JZW6, D3ZKF6
    Related
    ENSRNOP00000034132.4, ENSRNOT00000037360.6
    Conserved Domains (2) summary
    smart00676
    Location:75 → 182
    DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases
    pfam06565
    Location:453 → 485
    DUF1126; Repeat of unknown function (DUF1126)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    7943603..8144073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601976.3 → XP_017457465.1  EF-hand domain-containing family member C2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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