Tbc1d25 TBC1 domain family, member 25 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbc1d25provided by RGD
Official Full Name: TBC1 domain family, member 25provided by RGD
Primary source: RGD:1559711
See related: Ensembl:ENSRNOG00000005303 AllianceGenome:RGD:1559711
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oatl1; RGD1559711
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and regulation of autophagosome maturation. Predicted to be active in autophagosome. Orthologous to human TBC1D25 (TBC1 domain family member 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 33.5), Kidney (RPKM 33.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (16986629..17010228)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (14314095..14339171)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (15064733..15088579)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
Title: TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagosome maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TBC1 domain family member 25

Names: ornithine aminotransferase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106955.2 → NP_001100425.1 TBC1 domain family member 25

See identical proteins and their annotated locations for NP_001100425.1

Status: PROVISIONAL

Source sequence(s)

BC161862

UniProtKB/TrEMBL

B1WBS1, F7F8Z1

Related

ENSRNOP00000007130.5, ENSRNOT00000007130.7

Conserved Domains (1) summary

smart00164
Location:225 → 454

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

16986629..17010228

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601993.3 → XP_017457482.1 TBC1 domain family member 25 isoform X2

UniProtKB/TrEMBL

A0A8I6ALA8
XM_063279918.1 → XP_063135988.1 TBC1 domain family member 25 isoform X3
XM_063279917.1 → XP_063135987.1 TBC1 domain family member 25 isoform X3
XM_006256701.5 → XP_006256763.1 TBC1 domain family member 25 isoform X1

UniProtKB/TrEMBL

A0A8I6ALA8

Conserved Domains (1) summary

smart00164
Location:193 → 422

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs