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Acot9 acyl-CoA thioesterase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302640, updated on 11-Apr-2024

Summary

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Official Symbol
Acot9provided by RGD
Official Full Name
acyl-CoA thioesterase 9provided by RGD
Primary source
RGD:1359188
See related
Ensembl:ENSRNOG00000003782 AllianceGenome:RGD:1359188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acate2
Summary
Predicted to enable acetyl-CoA hydrolase activity and palmitoyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and short-chain fatty acid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 264.7), Heart (RPKM 225.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (43922943..43973311, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (40073197..40123573, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (43543069..43592200, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 4 Neighboring gene E3 ubiquitin-protein ligase RNF168-like Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene spermidine/spermine N1-acetyl transferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. Poupon V, et al. J Biol Chem, 1999 Jul 2. PMID 10383425
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. Hunt MC, et al. J Lipid Res, 2005 Sep. PMID 16103133
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in short-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-coenzyme A thioesterase 9, mitochondrial
Names
acyl-Coenzyme A thioesterase 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013960.1 → NP_001013982.1  acyl-coenzyme A thioesterase 9, mitochondrial

    See identical proteins and their annotated locations for NP_001013982.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085822
    UniProtKB/TrEMBL
    F7ETS0, Q5U2X8
    Related
    ENSRNOP00000005033.5, ENSRNOT00000005033.6
    Conserved Domains (1) summary
    cd03442
    Location:286 → 406
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    43922943..43973311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099645.2 → XP_038955573.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6IPR3, F7ETS0
    Conserved Domains (1) summary
    PLN02647
    Location:3 → 336
    PLN02647; acyl-CoA thioesterase

  2. XM_039099644.2 → XP_038955572.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6IPR3, F7ETS0
    Conserved Domains (1) summary
    PLN02647
    Location:3 → 336
    PLN02647; acyl-CoA thioesterase
Nucleotide Protein Strain
Heading Accession and Version

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