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Frmpd4 FERM and PDZ domain containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302656, updated on 25-Apr-2024

Summary

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Official Symbol
Frmpd4provided by RGD
Official Full Name
FERM and PDZ domain containing 4provided by RGD
Primary source
RGD:1566031
See related
Ensembl:ENSRNOG00000004118 AllianceGenome:RGD:1566031
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566031
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Involved in postsynaptic actin cytoskeleton organization. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 104. Orthologous to human FRMPD4 (FERM and PDZ domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 140.2) and Lung (RPKM 6.3) See more
Orthologs
human mouse all
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Genomic context

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See Frmpd4 in Genome Data Viewer
Location:
Xq13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (29739834..30386917)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (25853849..26814642)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (27231648..28206890)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene MSL complex subunit 3 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene FANCD2 opposite strand like 2 Neighboring gene FANCD2 opposite strand like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Preso1 dynamically regulates group I metabotropic glutamate receptors. Hu JH, et al. Nat Neurosci, 2012 Jun. PMID 22561452, Free PMC Article
  2. Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. Lee HW, et al. J Neurosci, 2008 Dec 31. PMID 19118189, Free PMC Article
  3. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Yuzawa S, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22074847, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways.
    Title: Downregulation of Preso protects against ischemic/reperfusion-mediated neuronal injury through regulating PSD95-nNOS/YAP pathways.
  2. We identified and cloned a full-length gene determined to be homologous to human FRMPD4 and is here termed Preso1.
    Title: Preso1 dynamically regulates group I metabotropic glutamate receptors.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FERM and PDZ domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106960.1 → NP_001100430.1  FERM and PDZ domain-containing protein 4

    See identical proteins and their annotated locations for NP_001100430.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474014
    UniProtKB/TrEMBL
    A0A8I6GKT4, A6K2F7, D4A3K7
    Related
    ENSRNOP00000093782.1, ENSRNOT00000104697.1
    Conserved Domains (5) summary
    smart00295
    Location:151 → 370
    B41; Band 4.1 homologues
    cd00992
    Location:22 → 98
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:366 → 470
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    pfam00373
    Location:246 → 370
    FERM_M; FERM central domain
    pfam16511
    Location:151 → 184
    FERM_f0; N-terminal or F0 domain of Talin-head FERM

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    29739834..30386917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601999.3 → XP_017457488.1  FERM and PDZ domain-containing protein 4 isoform X3

    UniProtKB/TrEMBL
    D4A3K7

  2. XM_063279932.1 → XP_063136002.1  FERM and PDZ domain-containing protein 4 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ALF4

  3. XM_039099649.2 → XP_038955577.1  FERM and PDZ domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    D4A3K7
    Conserved Domains (6) summary
    smart00295
    Location:197 → 416
    B41; Band 4.1 homologues
    cd00201
    Location:28 → 57
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:68 → 144
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:412 → 516
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17170
    Location:193 → 286
    FERM_F1_FRMPD4; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 4 (FRMPD4)
    cd21943
    Location:965 → 1013
    LGNbd_FRMPD4; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 4

  4. XM_063279930.1 → XP_063136000.1  FERM and PDZ domain-containing protein 4 isoform X2

  5. XM_017602000.3 → XP_017457489.1  FERM and PDZ domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    D4A3K7
    Conserved Domains (6) summary
    smart00295
    Location:197 → 416
    B41; Band 4.1 homologues
    cd00201
    Location:28 → 57
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:68 → 144
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:412 → 516
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17170
    Location:193 → 286
    FERM_F1_FRMPD4; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 4 (FRMPD4)
    cd21943
    Location:965 → 1013
    LGNbd_FRMPD4; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 4

  6. XM_017601998.3 → XP_017457487.1  FERM and PDZ domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALA6, D4A3K7
    Related
    ENSRNOP00000094044.1

  7. XM_063279931.1 → XP_063136001.1  FERM and PDZ domain-containing protein 4 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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