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Car5b carbonic anhydrase 5B [ Rattus norvegicus (Norway rat) ]

Gene ID: 302669, updated on 5-Mar-2024

Summary

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Official Symbol
Car5bprovided by RGD
Official Full Name
carbonic anhydrase 5Bprovided by RGD
Primary source
RGD:1549783
See related
Ensembl:ENSRNOG00000029330 AllianceGenome:RGD:1549783
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ca5b
Summary
Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to act upstream of or within response to bacterium. Predicted to be active in mitochondrion. Orthologous to human CA5B (carbonic anhydrase 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 532.7), Lung (RPKM 95.4) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Car5b in Genome Data Viewer
Location:
Xq14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (34106553..34166651)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30474697..30534797)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (32232106..32291124)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 2 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 Neighboring gene adaptor related protein complex 1 subunit sigma 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. Shah GN, et al. Proc Natl Acad Sci U S A, 2000 Feb 15. PMID 10677517, Free PMC Article
  2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC93720

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables carbonate dehydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
carbonic anhydrase 5B, mitochondrial
Names
CA-VB
carbonate dehydratase VB
carbonic anhydrase VB, mitochondrial
NP_001005551.1
XP_006256921.1
XP_038955584.1
XP_038955585.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005551.2 → NP_001005551.1  carbonic anhydrase 5B, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001005551.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081872
    UniProtKB/Swiss-Prot
    Q66HG6
    UniProtKB/TrEMBL
    A0A8I5ZPN0, A6K2L9
    Related
    ENSRNOP00000080254.1, ENSRNOT00000101751.1
    Conserved Domains (1) summary
    cl00012
    Location:61 → 296
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    34106553..34166651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256859.4 → XP_006256921.1  carbonic anhydrase 5B, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006256921.1

    UniProtKB/Swiss-Prot
    Q66HG6
    UniProtKB/TrEMBL
    A0A8I5ZPN0, A6K2L9
    Related
    ENSRNOP00000043235.3, ENSRNOT00000047354.5
    Conserved Domains (1) summary
    cl00012
    Location:61 → 296
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  2. XM_039099657.1 → XP_038955585.1  carbonic anhydrase 5B, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZPN0
    Conserved Domains (1) summary
    cl00012
    Location:61 → 264
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  3. XM_039099656.1 → XP_038955584.1  carbonic anhydrase 5B, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q66HG6
    UniProtKB/TrEMBL
    A0A8I5ZPN0, A6K2L9
    Conserved Domains (1) summary
    cl00012
    Location:61 → 296
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HG6.1 GenPept UniProtKB/Swiss-Prot:Q66HG6

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