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Enox2 ecto-NOX disulfide-thiol exchanger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302817, updated on 13-Apr-2024

Summary

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Official Symbol
Enox2provided by RGD
Official Full Name
ecto-NOX disulfide-thiol exchanger 2provided by RGD
Primary source
RGD:1563643
See related
Ensembl:ENSRNOG00000030622 AllianceGenome:RGD:1563643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cova1; RGD1563643
Summary
Predicted to enable protein-disulfide reductase activity. Predicted to be involved in electron transport chain and ultradian rhythm. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human ENOX2 (ecto-NOX disulfide-thiol exchanger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 28.1), Muscle (RPKM 21.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Enox2 in Genome Data Viewer
Location:
Xq36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (133148813..133470914, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (128270941..128593074, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135918938..136303267, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 49 Neighboring gene fibrous sheath-interacting protein 2 like 1 Neighboring gene eukaryotic translation initiation factor 4B-like Neighboring gene Rho GTPase activating protein 36 Neighboring gene high mobility group protein B4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biochemical basis for the biological clock. Morré DJ, et al. Biochemistry, 2002 Oct 8. PMID 12356293
  2. Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface. Chueh PJ, et al. Biochemistry, 2002 Mar 19. PMID 11888291
  3. Surface NADH oxidase of HeLa cells lacks intrinsic membrane binding motifs. Morré DJ, et al. Arch Biochem Biophys, 2001 Aug 15. PMID 11488599
  4. [Mitral valve aneurysm associated with mitral insufficiency in absence of aortic insufficiency]. Tarasoutchi F, et al. Arq Bras Cardiol, 1991 Mar. PMID 1888291
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in electron transport chain ISO
Inferred from Sequence Orthology
more info
  
involved_in ultradian rhythm ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ecto-NOX disulfide-thiol exchanger 2
Names
cytosolic ovarian carcinoma antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427048.1 → NP_001413977.1  ecto-NOX disulfide-thiol exchanger 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    133148813..133470914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017602398.3 → XP_017457887.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

    UniProtKB/TrEMBL
    A0A1W2Q6I1, A0A1W2Q6P9, A6JMR6, A6JMR8
    Conserved Domains (2) summary
    COG0724
    Location:90 → 168
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12228
    Location:93 → 176
    RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

  2. XM_039100556.2 → XP_038956484.1  ecto-NOX disulfide-thiol exchanger 2 isoform X4

    UniProtKB/TrEMBL
    A0A1W2Q6P9, A6JMR8
    Conserved Domains (1) summary
    cd12228
    Location:108 → 191
    RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

  3. XM_063279958.1 → XP_063136028.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

    UniProtKB/TrEMBL
    A0A1W2Q6I1, A6JMR6

  4. XM_008773547.4 → XP_008771769.2  ecto-NOX disulfide-thiol exchanger 2 isoform X2

    UniProtKB/TrEMBL
    A0A1W2Q6P9, A6JMR8

  5. XM_039100555.2 → XP_038956483.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

    UniProtKB/TrEMBL
    A0A1W2Q6P9, A6JMR8, D3Z9Z5
    Related
    ENSRNOP00000050076.4
    Conserved Domains (1) summary
    cd12228
    Location:113 → 196
    RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

  6. XM_017602395.3 → XP_017457884.1  ecto-NOX disulfide-thiol exchanger 2 isoform X1

    UniProtKB/TrEMBL
    A0A1W2Q6P9, A6JMR8
Nucleotide Protein Strain
Heading Accession and Version

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