Cpeb4 cytoplasmic polyadenylation element binding protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cpeb4provided by RGD
Full Name: cytoplasmic polyadenylation element binding protein 4provided by RGD
Primary source: RGD:1311931
See related: Ensembl:ENSRNOG00000033169 AllianceGenome:RGD:1311931
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA 3'-UTR binding activity; ribosome binding activity; and translation regulator activity, nucleic acid binding. Involved in several processes, including cellular response to glucose starvation; ionotropic glutamate receptor signaling pathway; and negative regulation of neuron apoptotic process. Located in cytoplasm; dendrite; and nucleus. Is active in postsynapse. Orthologous to human CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 346.5), Kidney (RPKM 339.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (16222271..16284248, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (15717794..15780482, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (15984520..16047209, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identify a mechanism of VEGF overexpression in liver and mesentery that promotes pathologic, but not physiologic, angiogenesis, via sequential and nonredundant functions of CPEB1 and CPEB4.
Title: Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease.
Data show that treatment of neurons with ionotropic glutamate receptor agonists causes CPEB4 to accumulate in the nucleus.
Title: CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE102188 (e-PCR)
- UniSTS:244085

BI293756 (e-PCR)
- UniSTS:245703

BE121203 (e-PCR)
- UniSTS:248033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to decreased oxygen levels	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106992.1 → NP_001100462.1 cytoplasmic polyadenylation element-binding protein 4

See identical proteins and their annotated locations for NP_001100462.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A0A8I6A633, A6HDC7, D3ZKL3

Related

ENSRNOP00000060861.1, ENSRNOT00000064832.3

Conserved Domains (3) summary

pfam16366
Location:647 → 708

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:464 → 555

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:572 → 652

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

16222271..16284248 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245980.4 → XP_006246042.1 cytoplasmic polyadenylation element-binding protein 4 isoform X3

UniProtKB/TrEMBL

A0A8I6A633

Related

ENSRNOP00000088235.1

Conserved Domains (3) summary

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_006245979.4 → XP_006246041.1 cytoplasmic polyadenylation element-binding protein 4 isoform X2

UniProtKB/TrEMBL

A0A8I5ZK67

Related

ENSRNOP00000076916.1

Conserved Domains (3) summary

pfam16366
Location:638 → 699

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:455 → 546

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:563 → 643

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_006245978.4 → XP_006246040.1 cytoplasmic polyadenylation element-binding protein 4 isoform X1

UniProtKB/TrEMBL

A0A0G2K3Y6, A0A8I5ZK67

Related

ENSRNOP00000072827.1

Conserved Domains (3) summary

pfam16366
Location:655 → 716

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:472 → 563

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:580 → 660

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_039085883.2 → XP_038941811.1 cytoplasmic polyadenylation element-binding protein 4 isoform X4

Conserved Domains (3) summary

pfam16366
Location:221 → 282

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

cd12724
Location:38 → 129

RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:146 → 226

RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
XM_063268952.1 → XP_063125022.1 cytoplasmic polyadenylation element-binding protein 4 isoform X4